The aging lung: Physiology, disease, and immunity.
The aging lung: Physiology, disease, and immunity.
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衰老的肺：生理学、疾病和免疫。
DOI：
10.1016/j.cell.2021.03.005
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发表时间：
2021-04-15
期刊：
影响因子：
64.5
通讯作者：
Haigis MC
中科院分区：
文献类型：
--
作者：
Schneider JL;Rowe JH;Garcia-de-Alba C;Kim CF;Sharpe AH;Haigis MC
人口老龄化的速度在人类历史上前所未见。随着老年人数量的增长，我们必须扩大对衰老生物学基础的理解。人的肺是由一系列独特的细胞类型组成的，这些细胞在一生中面临持续的化学、机械、生物、免疫和异种应激。然而，我们并不完全理解肺老化的机制驱动因素，以及为什么年龄增加了实质性肺部疾病、致命性呼吸道感染和原发性肺癌的风险。在这里，我们回顾了肺老化的分子和细胞方面，局部应激反应途径，以及衰老过程如何导致肺部疾病的发病机制。我们将这些见解置于新冠肺炎大流行的背景下，讨论肺内的先天性和获得性免疫是如何随着年龄的变化而改变的。最近的细胞和分子研究揭示了为什么从肺癌到新冠肺炎等许多肺部疾病的发病率和/或严重性随着年龄的增长而增加。
The population is aging at a rate never seen before in human history. As the number of elderly adults grows, it is imperative we expand our understanding of the underpinnings of aging biology. Human lungs are composed of a unique panoply of cell types that face ongoing chemical, mechanical, biological, immunological, and xenobiotic stress over a lifetime. Yet, we do not fully appreciate the mechanistic drivers of lung aging and why age increases the risk of parenchymal lung disease, fatal respiratory infection, and primary lung cancer. Here, we review the molecular and cellular aspects of lung aging, local stress response pathways, and how the aging process predisposes to the pathogenesis of pulmonary disease. We place these insights into context of the COVID-19 pandemic and discuss how innate and adaptive immunity within the lung is altered with age. Recent cellular and molecular studies have given insight into why the incidence and/or severity of many lung diseases, from lung cancer to COVID-19, increase with age.
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危及生命的Covid-19患者中针对I型IFN的自身抗体。
DOI：
10.1126/science.abd4585
发表时间：
2020-10-23
期刊：
Science (New York, N.Y.)
影响因子：
--
作者：
Bastard P;Rosen LB;Zhang Q;Michailidis E;Hoffmann HH;Zhang Y;Dorgham K;Philippot Q;Rosain J;Béziat V;Manry J;Shaw E;Haljasmägi L;Peterson P;Lorenzo L;Bizien L;Trouillet-Assant S;Dobbs K;de Jesus AA;Belot A;Kallaste A;Catherinot E;Tandjaoui-Lambiotte Y;Le Pen J;Kerner G;Bigio B;Seeleuthner Y;Yang R;Bolze A;Spaan AN;Delmonte OM;Abers MS;Aiuti A;Casari G;Lampasona V;Piemonti L;Ciceri F;Bilguvar K;Lifton RP;Vasse M;Smadja DM;Migaud M;Hadjadj J;Terrier B;Duffy D;Quintana-Murci L;van de Beek D;Roussel L;Vinh DC;Tangye SG;Haerynck F;Dalmau D;Martinez-Picado J;Brodin P;Nussenzweig MC;Boisson-Dupuis S;Rodríguez-Gallego C;Vogt G;Mogensen TH;Oler AJ;Gu J;Burbelo PD;Cohen JI;Biondi A;Bettini LR;D'Angio M;Bonfanti P;Rossignol P;Mayaux J;Rieux-Laucat F;Husebye ES;Fusco F;Ursini MV;Imberti L;Sottini A;Paghera S;Quiros-Roldan E;Rossi C;Castagnoli R;Montagna D;Licari A;Marseglia GL;Duval X;Ghosn J;HGID Lab;NIAID-USUHS Immune Response to COVID Group;COVID Clinicians;COVID-STORM Clinicians;Imagine COVID Group;French COVID Cohort Study Group;Milieu Intérieur Consortium;CoV-Contact Cohort;Amsterdam UMC Covid-19 Biobank;COVID Human Genetic Effort;Tsang JS;Goldbach-Mansky R;Kisand K;Lionakis MS;Puel A;Zhang SY;Holland SM;Gorochov G;Jouanguy E;Rice CM;Cobat A;Notarangelo LD;Abel L;Su HC;Casanova JL
通讯作者：
Casanova JL
影响因子：
16.6
作者：
Angelidis, Ilias;Simon, Lukas M.;Schiller, Herbert B.
通讯作者：
Schiller, Herbert B.
DOI：
10.1096/fj.201800965r
发表时间：
2019-03
期刊：
FASEB journal : official publication of the Federation of American Societies for Experimental Biology
影响因子：
--
作者：
Baker JR;Vuppusetty C;Colley T;Hassibi S;Fenwick PS;Donnelly LE;Ito K;Barnes PJ
通讯作者：
Barnes PJ
影响因子：
5
作者：
BEATY, TH;COHEN, BH;CHEN, CJ
通讯作者：
CHEN, CJ
影响因子：
4.6
作者：
Baker JR;Vuppusetty C;Colley T;Papaioannou AI;Fenwick P;Donnelly L;Ito K;Barnes PJ
通讯作者：
Barnes PJ