Hormonal regulation of the hypothalamic melanocortin system.
Hormonal regulation of the hypothalamic melanocortin system.
复制标题
DOI：
10.3389/fphys.2014.00480
复制
发表时间：
2014
影响因子：
4
通讯作者：
Diano S
中科院分区：
文献类型：
--
作者：
Kim JD;Leyva S;Diano S
能量平衡的调节是生命的基础。在动物物种和人类中，中枢神经系统（CNS）通过整合外周信号并调节外周器官的行为和活动在这种调节中起关键作用。中枢神经系统和外周信号之间的精确相互作用对于调节食物摄入和能量消耗以维持能量平衡是必要的。在中枢神经系统内，下丘脑是监测、处理和响应外周信号的关键中心，包括激素如生长激素释放肽、瘦素和胰岛素。一旦进入大脑，外周信号调节参与能量稳态调节的神经元系统。调节能量代谢的主要下丘脑神经元回路是黑皮质素系统。本文就下丘脑黑皮质素系统在能量稳态控制中的激素调节作用作一综述。
Regulation of energy homeostasis is fundamental for life. In animal species and humans, the Central Nervous System (CNS) plays a critical role in such regulation by integrating peripheral signals and modulating behavior and the activity of peripheral organs. A precise interplay between CNS and peripheral signals is necessary for the regulation of food intake and energy expenditure in the maintenance of energy balance. Within the CNS, the hypothalamus is a critical center for monitoring, processing and responding to peripheral signals, including hormones such as ghrelin, leptin, and insulin. Once in the brain, peripheral signals regulate neuronal systems involved in the modulation of energy homeostasis. The main hypothalamic neuronal circuit in the regulation of energy metabolism is the melanocortin system. This review will give a summary of the most recent discoveries on the hormonal regulation of the hypothalamic melanocortin system in the control of energy homeostasis.
登录
查看更多内容
影响因子：
56.9
作者：
Cota, D;Proulx, K;Seeley, RJ
通讯作者：
Seeley, RJ
影响因子：
16.2
作者：
Cowley, MA;Smith, RG;Horvath, TL
通讯作者：
Horvath, TL
影响因子：
64.5
作者：
Chen, H;Charlat, O;Morgenstern, JP
通讯作者：
Morgenstern, JP
影响因子：
16.2
作者：
Cowley, MA;Pronchuk, N;Cone, RD
通讯作者：
Cone, RD
影响因子：
4.8
作者：
Diano, S;Naftolin, F;Horvath, TL
通讯作者：
Horvath, TL