Cannabidiol for neurodegenerative disorders: A comprehensive review.
Cannabidiol for neurodegenerative disorders: A comprehensive review.
复制标题
DOI：
10.3389/fphar.2022.989717
复制
发表时间：
2022
影响因子：
5.6
通讯作者：
中科院分区：
文献类型：
--
作者：
尽管神经学取得了重大进展，但迄今为止，治疗神经退行性疾病仍然是一项艰巨的任务。在神经退行性疾病复杂的病因中，神经炎症和氧化应激在其发病中起主要作用。为此，从大麻（俗称大麻）中分离出的一些植物大麻素作为潜在的神经治疗药物引起了极大的关注。∆9-四氢大麻酚（THC）是大麻的主要精神活性成分，其深远的作用导致了内源性大麻素系统作为中枢神经系统（CNS）中的分子靶点的发现。大麻二酚（CBD）是大麻中主要的非精神活性成分，由于其抗氧化和抗炎特性以及耐受性良好的药理行为，近年来成为神经保护药物开发的潜在原型。本文简要讨论了炎症和氧化应激在神经变性中的作用，并论证了大麻二酚的神经保护作用，重点介绍了其在帕金森病（PD）和阿尔茨海默病（AD）中的一般作用机制和疾病特异性途径。此外，我们总结了CBD在PD和AD治疗前景的临床前和临床研究结果，阐明了确定其治疗窗口期的重要性，并为确定有前景的新研究方向提供了见解。
Despite the significant advances in neurology, the cure for neurodegenerative conditions remains a formidable task to date. Among various factors arising from the complex etiology of neurodegenerative diseases, neuroinflammation and oxidative stress play a major role in pathogenesis. To this end, some phytocannabinoids isolated from Cannabis sativa (widely known as marijuana) have attracted significant attention as potential neurotherapeutics. The profound effect of ∆9-tetrahydrocannabinol (THC), the major psychoactive component of cannabis, has led to the discovery of the endocannabinoid system as a molecular target in the central nervous system (CNS). Cannabidiol (CBD), the major non-psychoactive component of cannabis, has recently emerged as a potential prototype for neuroprotective drug development due to its antioxidant and anti-inflammatory properties and its well-tolerated pharmacological behavior. This review briefly discusses the role of inflammation and oxidative stress in neurodegeneration and demonstrates the neuroprotective effect of cannabidiol, highlighting its general mechanism of action and disease-specific pathways in Parkinson’s disease (PD) and Alzheimer’s disease (AD). Furthermore, we have summarized the preclinical and clinical findings on the therapeutic promise of CBD in PD and AD, shed light on the importance of determining its therapeutic window, and provide insights into identifying promising new research directions.
登录
查看更多内容
影响因子：
4.8
作者：
Devi, Latha;Raghavendran, Vijayendran;Anandatheerthavarada, Hindupur K.
通讯作者：
Anandatheerthavarada, Hindupur K.
影响因子：
5.6
作者：
Coles M;Watt G;Kreilaus F;Karl T
通讯作者：
Karl T
影响因子：
3.8
作者：
da Silva, Vanessa Kappel;de Freitas, Betania Souza;Schroder, Nadja
通讯作者：
Schroder, Nadja
影响因子：
4
作者：
Cheng, David;Spiro, Adena S.;Karl, Tim
通讯作者：
Karl, Tim
影响因子：
5.1
作者：
Cooray R;Gupta V;Suphioglu C
通讯作者：
Suphioglu C