An international comparison of retinopathy of prematurity grading performance within the Benefits of Oxygen Saturation Targeting II trials.
An international comparison of retinopathy of prematurity grading performance within the Benefits of Oxygen Saturation Targeting II trials.
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DOI：
10.1038/eye.2017.150
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发表时间：
2018-01
期刊：
影响因子：
--
通讯作者：
BOOST II Retinal Image Digital Analysis (RIDA) Group
中科院分区：
文献类型：
--
作者：
Fleck BW;Williams C;Juszczak E;Cocker K;Stenson BJ;Darlow BA;Dai S;Gole GA;Quinn GE;Wallace DK;Ells A;Carden S;Butler L;Clark D;Elder J;Wilson C;Biswas S;Shafiq A;King A;Brocklehurst P;Fielder AR;BOOST II Retinal Image Digital Analysis (RIDA) Group
研究在氧饱和度靶向获益（BOOST）II试验中观察到的早产儿视网膜病变（ROP）治疗率的国际差异是否可能是由ROP疾病分级的国际差异引起的。英国、澳大利亚和新西兰（ANZ）的BOOST II试验眼科医生组以及国际参考组（INT）使用基于网络的系统对BOOST II英国试验期间采集的ROP RetCam图像进行分级。测量治疗决定率，加上疾病分级、ROP分期分级、ROP区域分级、组内观察者间变异和组内观察者间变异。对42项眼科检查进行了分级。英国眼科医生诊断为需要治疗的ROP的频率高于ANZ眼科医生，13.9（3.49）例与9.4（4.46）例眼部检查，P=0.038。英国眼科医生诊断为+疾病的频率高于ANZ眼科医生，14.1（6.23）与8.5（3.24）眼检查，P=0.021。ANZ眼科医生诊断2期ROP的频率高于英国眼科医生，分别为20.2（5.8）次和12.7（7.1）次眼科检查，P=0.026。在ROP分期或区域的分级方面没有其他显著差异。英国组的观察者间差异高于ANZ组。两组的观察者内变异均较低。我们已经发现了在诊断需要治疗的ROP方面存在国际差异的证据。需要改善需要治疗的ROP的诊断标准化。采取的措施可能包括改进使用国际方法对ROP进行分级的培训，以及进一步开发ROP图像分析软件。
To investigate whether the observed international differences in retinopathy of prematurity (ROP) treatment rates within the Benefits of Oxygen Saturation Targeting (BOOST) II trials might have been caused by international variation in ROP disease grading. Groups of BOOST II trial ophthalmologists in UK, Australia, and New Zealand (ANZ), and an international reference group (INT) used a web based system to grade a selection of RetCam images of ROP acquired during the BOOST II UK trial. Rates of decisions to treat, plus disease grading, ROP stage grading, ROP zone grading, inter-observer variation within groups and intra-observer variation within groups were measured. Forty-two eye examinations were graded. UK ophthalmologists diagnosed treat-requiring ROP more frequently than ANZ ophthalmologists, 13.9 (3.49) compared to 9.4 (4.46) eye examinations, P=0.038. UK ophthalmologists diagnosed plus disease more frequently than ANZ ophthalmologists, 14.1 (6.23) compared to 8.5 (3.24) eye examinations, P=0.021. ANZ ophthalmologists diagnosed stage 2 ROP more frequently than UK ophthalmologists, 20.2 (5.8) compared to 12.7 (7.1) eye examinations, P=0.026. There were no other significant differences in the grading of ROP stage or zone. Inter-observer variation was higher within the UK group than within the ANZ group. Intra-observer variation was low in both groups. We have found evidence of international variation in the diagnosis of treatment-requiring ROP. Improved standardisation of the diagnosis of treatment-requiring ROP is required. Measures might include improved training in the grading of ROP, using an international approach, and further development of ROP image analysis software.
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影响因子：
1.7
作者：
Ataer-Cansizoglu, E.;Kalpathy-Cramer, J.;Chiang, M. F.
通讯作者：
Chiang, M. F.
影响因子：
1.6
作者：
Myung, Jane S.;Chan, Robison Vernon Paul;Chiang, Michael F.
通讯作者：
Chiang, Michael F.
影响因子：
5.1
作者：
Darlow, Brian A.;Marschner, Simone L.;Tarnow-Mordi, William O.
通讯作者：
Tarnow-Mordi, William O.
影响因子：
3.6
作者：
Blencowe, Hannah;Lawn, Joy E.;Vazquez, Thomas;Fielder, Alistair;Gilbert, Clare
通讯作者：
Gilbert, Clare
DOI：
10.1056/nejmoa0911781
发表时间：
2010-05-27
期刊：
The New England journal of medicine
影响因子：
--
作者：
SUPPORT Study Group of the Eunice Kennedy Shriver NICHD Neonatal Research Network;Carlo WA;Finer NN;Walsh MC;Rich W;Gantz MG;Laptook AR;Yoder BA;Faix RG;Das A;Poole WK;Schibler K;Newman NS;Ambalavanan N;Frantz ID 3rd;Piazza AJ;Sánchez PJ;Morris BH;Laroia N;Phelps DL;Poindexter BB;Cotten CM;Van Meurs KP;Duara S;Narendran V;Sood BG;O'Shea TM;Bell EF;Ehrenkranz RA;Watterberg KL;Higgins RD
通讯作者：
Higgins RD