Oral administration of fructose-1,6-diphosphate has anticonvulsant activity.
Oral administration of fructose-1,6-diphosphate has anticonvulsant activity.
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口服果糖-1,6-二磷酸具有抗惊厥活性。
DOI：
10.1016/j.neulet.2008.09.042
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发表时间：
2008-12-03
影响因子：
2.5
通讯作者：
Stringer, Janet L.
中科院分区：
文献类型：
--
作者：
Lian, Xiao-Yuan;Xu, Kaiping;Stringer, Janet L.
最近研究表明，1，6-二磷酸果糖（FDP）在化学惊厥药诱导的大鼠急性全身运动性癫痫发作模型中具有剂量依赖性抗惊厥活性。本研究询问口服给药后FDP是否在癫痫脑中也具有活性，以及是否对非惊厥性癫痫发作具有活性。动物（n=14）给予毛果芸香碱诱导癫痫持续状态。几周后，这些动物出现自发性癫痫发作，并在6天内确定癫痫发作频率的基线率。然后动物继续不处理（n=8）或将0.5%FDP添加至饮用水（n=6）。在用FDP处理的动物中，癫痫发作在7天后完全停止。经过16天的观察，从水中去除FDP导致6只动物中的4只恢复癫痫发作活动。为诱导非惊厥性癫痫发作，动物（n=6）接受γ-丁内酯（GBL，100 mg/kg ip）单次注射。在GBL给药后几分钟内，所有动物的皮质中都记录到了棘波活动。单次注射FDP（500 g/kg ip）对基线皮质活动没有影响，对GBL诱导的棘波活动也没有影响（n=5）。这些实验表明，口服给药FDP可用于治疗部分或全身性惊厥性癫痫发作，但不适用于失神性癫痫发作。
Recently it has been shown that fructose-1,6-diphosphate (FDP) has dose-dependent anticonvulsant activity in rat models of acute generalized motor seizures induced with chemical convulsants. This present study asked whether FDP also has activity in an epileptic brain after oral administration and activity against non-convulsive seizures. Animals (n=14) were administered pilocarpine to induce status epilepticus. Several weeks later, these animals had spontaneous seizures and a baseline rate of seizure frequency was determined over a 6 day period. Animals were then continued without treatment (n=8) or 0.5% FDP was added to the drinking water (n=6). In animals treated with FDP the seizures completely stopped after 7 days. Removal of FDP from the water resulted in the return of seizure activity in 4 of the 6 animals by 16 days of observation. To induce non-convulsive seizures, animals (n=6) received a single injection of γ-butyrolactone (GBL, 100 mg/kg ip). All animals had spike-wave activity recorded in the cortex within minutes after GBL administration. Administration of a single injection of FDP (500 g/kg ip) had no effect on the baseline cortical activity, nor on the spike-wave activity induced by GBL (n=5). These experiments suggest that oral administration of FDP may have utility in the treatment of partial or generalized convulsive seizure disorders, but not absence seizures.
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影响因子：
2.2
作者：
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