Upregulated CD58 is associated with clinicopathological characteristics and poor prognosis of patients with pancreatic ductal adenocarcinoma.
Upregulated CD58 is associated with clinicopathological characteristics and poor prognosis of patients with pancreatic ductal adenocarcinoma.
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CD58上调与胰腺导管腺癌患者的临床病理特征和不良预后相关
DOI：
10.1186/s12935-021-02037-0
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发表时间：
2021-06-30
影响因子：
5.8
通讯作者：
Liao Q
中科院分区：
文献类型：
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作者：
Zhang Y;Liu Q;Liu J;Liao Q
CD 58在多种造血系统恶性肿瘤和实体瘤中异常表达，在肿瘤的发生和发展中起重要作用，但其在胰腺导管腺癌（PDAC）中的临床意义和预后价值尚不清楚。基于不同的在线公共数据库和81例PDAC样本的组织芯片免疫组化（IHC），我们评估了PDAC患者的CD 58表达，并分析了其与临床病理特征，临床结局和免疫细胞浸润的相关性。同时检测CD 58与肿瘤干细胞（CSC）相关、上皮间质转化（EMT）相关和免疫相关标志物的相关性。此外，功能富集分析和相关途径进行了分析和可视化。CD 58在胰腺炎和PDAC组织中的表达高于正常胰腺或邻近非肿瘤组织。PDAC中CD 58阳性（阳性细胞> 50%）占95.06%（77/81）。在PDAC患者中，癌组织中上调的CD 58与更差的组织学分级、更大的肿瘤大小、更差的总生存期和无病生存期相关。考克斯多因素回归分析显示CD 58是PDAC的独立预后因素。CD 58表达与中性粒细胞、CD 8 + T细胞和树突状细胞（DC）的浸润相关。此外，相关基因分析表明，CD 58表达与免疫相关，EMT相关和CSC相关标志物密切相关。功能富集分析和KEGG通路提示CD 58可能参与PDAC的发生和发展。CD 58在PDAC组织中表达上调，并且其高表达与PDAC的不良存活显著相关。因此，CD 58有可能成为预测PDAC患者预后的一个新的、有效的指标。在线版本包含补充材料，可通过10.1186/s12935-021-02037-0获得。
CD58 has been demonstrated to be abnormally expressed in multiple hematopoietic malignancies and solid tumors and plays an essential role in tumorigenesis and progression; however, its clinical significance and prognostic value in pancreatic ductal adenocarcinoma (PDAC) remain unknown. Based on diverse online public databases and 81 PDAC samples of tissue microarray-based immunohistochemistry (IHC), we evaluated CD58 expression in PDAC patients and analyzed its association with clinicopathological characteristics, clinical outcomes, and infiltration of immune cells in PDAC. Furthermore, the correlation between CD58 and the cancer stem cell (CSC)-related, epithelial–mesenchymal transition (EMT)-related, and immune-related markers were detected. Besides, the functional enrichment analysis and related pathways were analyzed and visualized. CD58 expression was elevated in pancreatitis and PDAC tissues than normal pancreas or adjacent nontumor tissues. The positive cases of CD58 (e.g. more than 50% positive cells) in PDAC account for 95.06% (77/81). Upregulated CD58 in cancer tissues was associated with worse histological grade, larger tumor size, and poorer overall survival and disease-free survival in PDAC patients. Furthermore, Cox multivariate regression analysis revealed that CD58 was an independent prognostic factor in PDAC. CD58 expression was correlated with infiltrations of neutrophils, CD8+ T cells, and dendritic cells (DCs). In addition, correlation gene analysis indicated that CD58 expression was strongly correlated with immune-related, EMT-related, and CSC-related markers. Functional enrichment analysis and KEGG pathway manifested that CD58 might be involved in PDAC initiation and progression. CD58 expression is upregulated in PDAC tissues and its high expression is notably related to poor survival of PDAC. Therefore, CD58 may serve as a novel and effective marker for predicting the prognosis of PDAC patients. The online version contains supplementary material available at 10.1186/s12935-021-02037-0.
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靶向胰腺导管腺癌中的树突状细胞。
影响因子：
5.8
作者：
Deicher A;Andersson R;Tingstedt B;Lindell G;Bauden M;Ansari D
通讯作者：
Ansari D
影响因子：
8.8
作者：
Ino Y;Yamazaki-Itoh R;Shimada K;Iwasaki M;Kosuge T;Kanai Y;Hiraoka N
通讯作者：
Hiraoka N
弥漫性大B细胞淋巴瘤中CD58和TP53基因的突变或拷贝数丢失是独立的不利预后因素
影响因子：
--
作者：
Cao Y;Zhu T;Zhang P;Xiao M;Yi S;Yang Y;Li Q;Ling S;Wang Y;Gao L;Zhu L;Wang J;Wang N;Huang L;Zhang P;Zhai Q;Qiu L;Zhou J
通讯作者：
Zhou J
DOI：
10.1093/bioinformatics/bts251
发表时间：
2012-07-01
期刊：
Bioinformatics (Oxford, England)
影响因子：
--
作者：
Jiao X;Sherman BT;Huang da W;Stephens R;Baseler MW;Lane HC;Lempicki RA
通讯作者：
Lempicki RA
影响因子：
8
作者：
Choi, MC;Jong, HS;Bang, YJ
通讯作者：
Bang, YJ