Carcinoembryonic Antigen Level in Primary Sclerosing Cholangitis Is Not Influenced by Dominant Strictures or Bacterial Cholangitis
Carcinoembryonic Antigen Level in Primary Sclerosing Cholangitis Is Not Influenced by Dominant Strictures or Bacterial Cholangitis
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原发性硬化性胆管炎的癌胚抗原水平不受显性狭窄或细菌性胆管炎的影响
DOI：
10.1007/s10620-016-4370-4
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发表时间：
2017
影响因子：
3.1
通讯作者：
Gotthardt DN
中科院分区：
文献类型：
--
作者：
Wannhoff A;Rupp C;Friedrich K;Knierim J;Flechtenmacher C;Weiss KH;Stremmel W;Gotthardt DN
背景癌胚抗原（CEA）可用于原发性硬化性胆管炎（PSC）患者的胆道癌筛查。目的探讨良性优势狭窄（DS）、叠加细菌性胆管炎（SBC）、吸烟状况和炎症性肠病对CEA血清水平的影响。方法回顾性分析无癌PSC患者的CEA值。我们纳入随访时获得的最大CEA值以及当时DS和SBC的存在信息，并分析DS和SBC存在和不存在时的CEA值。结果以四分位数范围（IQR）的中位数报告。结果最终纳入研究的270例PSC患者中，CEA的中位最高水平为1.8 ng/mL (IQR 1.2-2.9)，不受DS或SBC存在的影响（P= 0.320）。此外，在49例患者中，DS时的第一CEA值（1.5 ng/mL， IQR为1.2-2.1）与未DS时的第一CEA值（1.6 ng/mL， IQR为1.1-2.3）差异无统计学意义（P= 0.397）。最后，在24例患者中，无SBC时的CEA中位数（1.8 ng/mL， IQR为1.2-2.5）和SBC时的CEA中位数（1.8 ng/mL， IQR为1.0-3.0）具有可比性（P= 0.305）。吸烟不影响基于cea的癌症筛查。结论血清CEA水平不受DS或SBC的影响，可作为提高PSC患者癌症筛查的有利参数。
BackgroundCarcinoembryonic antigen (CEA) can be used to screen for biliary tract cancer in patients with primary sclerosing cholangitis (PSC).AimTo study the influence of benign dominant strictures (DS), superimposed bacterial cholangitis (SBC), smoking status, and inflammatory bowel disease on CEA serum levels.MethodsA retrospective analysis of CEA values in cancer-free PSC patients was performed. We included the maximal CEA value obtained during follow-up and information on the presence of DS and SBC at that time, and we analyzed the CEA values in the presence and absence of DS and SBC. Results are reported as medians with the interquartile range (IQR).ResultsThe median maximal CEA level, which was 1.8 ng/mL (IQR 1.2–2.9) in the final 270 PSC patients included in the study, was not influenced by the presence of either DS or SBC (P= 0.320). Moreover, in 49 patients, the first CEA value available at the time of DS (1.5 ng/mL; IQR 1.2–2.1) and that at a time without DS (1.6 ng/mL; IQR 1.1–2.3) did not differ significantly (P= 0.397). Lastly, in 24 patients, the median CEA values at a time without SBC (1.8 ng/mL; IQR 1.2–2.5) and at the time of SBC (1.8 ng/mL; IQR 1.0–3.0) were comparable (P= 0.305). Smoking did not influence CEA-based cancer screening.ConclusionsSerum CEA level is not influenced by the presence of DS or SBC and might therefore serve as a favorable parameter for improving cancer screening in PSC patients.
影响因子：
6
作者：
A. Wannhoff;T. Folseraas;M. Brune;C. Rupp;Kilian Friedrich;J. Knierim;K. Weiss;P. Sauer;C. Flechtenmacher;P. Schirmacher;W. Stremmel;J. Hov;D. Gotthardt
通讯作者：
A. Wannhoff;T. Folseraas;M. Brune;C. Rupp;Kilian Friedrich;J. Knierim;K. Weiss;P. Sauer;C. Flechtenmacher;P. Schirmacher;W. Stremmel;J. Hov;D. Gotthardt
影响因子：
25.7
作者：
Wannhoff, Andreas;Hov, Johannes Roksund;Gotthardt, Daniel Nils
通讯作者：
Gotthardt, Daniel Nils