Cell Cannibalism: A cytological study in effusion samples.
Cell Cannibalism: A cytological study in effusion samples.
复制标题
DOI：
10.4103/0970-9371.80736
复制
发表时间：
2011-04
影响因子：
1.3
通讯作者：
Misra J
中科院分区：
文献类型：
--
作者：
Bansal C;Tiwari V;Singh U;Srivastava A;Misra J
渗出液细胞学检查是诊断原发性或继发性恶性肿瘤的一种相对简便、快速的方法。分析恶性胸腔积液中细胞相残现象的细胞学意义。对100例恶性胸腔积液进行回顾性分析。这100例病例包括50例连续局部扩散至胸/腹水的病例。其余50例为播散性恶性肿瘤。排除了血液淋巴样恶性肿瘤引起的积液。评估这些病例的涂片是否存在细胞自食、肿瘤细胞内的肿瘤细胞。与连续局部扩散的病例（50例中的2例，即4%）相比，具有播散性恶性肿瘤的渗出液中的同类相食细胞更常见（50例中的9例，即18%）。卡方检验显示差异有统计学意义（x2 5.005，P=0.025）。肺癌占多数（6/11）。在细胞形态学上，显示吞噬功能的组织细胞可以模拟肿瘤细胞，需要加以区分。恶性积液中细胞自食现象的出现通常是继发性和更高肿瘤分期的播散性恶性肿瘤的指标。此外，同类相食可以提供一个可靠的预测肿瘤的进展，从原发到转移部位。
Cytological examination of effusion fluid is a relatively easy and quick method for the diagnosis of primary or secondary malignancy. To analyze the cytological significance of cell cannibalism in malignant effusion samples. A retrospective review of 100 cases of malignant effusion was done. These 100 cases included 50 cases of contiguous, local spread to pleural/ascitic fluid. The remaining 50 cases were of disseminated malignancy. Effusions due to hematolymphoid malignancies were excluded. Smears from these cases were assessed for the presence of cell cannibalism, tumor cell within a tumor cell. The cannibalistic cells were more common in effusions with disseminated malignancy (nine out of 50 cases i.e. 18%) compared with cases of contiguous, local spread (two out of 50 cases i.e. 4%). Chi square test showed this difference to be statistically significant (x2 5.005, P=0.025). The majority of the cases were of carcinoma lung (6/11). Cytomorphologically, histiocytes displaying phagocytosis can simulate tumor cells and need to be distinguished. Presence of cell cannibalism in malignant effusions is more often an indicator of disseminated malignancy with secondaries and higher tumor stage. Furthermore, cannibalism may provide a reliable predictor of progression of tumor from primary to the metastatic site.
登录
查看更多内容
影响因子：
1
作者：
Caruso, RA;Muda, AO;Inferrera, C
通讯作者：
Inferrera, C
影响因子：
11.2
作者：
Lugini, L;Matarrese, P;Fais, S
通讯作者：
Fais, S
影响因子：
1.3
作者：
Gupta, K;Dey, P
通讯作者：
Dey, P
影响因子：
1.7
作者：
Breier, F;Feldmann, R;Gschnait, F
通讯作者：
Gschnait, F
影响因子：
6.2
作者：
GUO, KJ;YAMAGUCHI, K;ENJOJI, M
通讯作者：
ENJOJI, M