Novel IL10 gene family associations with systemic juvenile idiopathic arthritis.
Novel IL10 gene family associations with systemic juvenile idiopathic arthritis.
复制标题
DOI：
10.1186/ar2041
复制
发表时间：
2006
影响因子：
4.9
通讯作者：
Woo P
中科院分区：
文献类型：
--
作者：
Fife MS;Gutierrez A;Ogilvie EM;Stock CJ;Samuel JM;Thomson W;Mack LF;Lewis CM;Woo P
幼年特发性关节炎(JIA)是导致儿童慢性残疾的最常见原因，包括许多疾病亚类。在这项研究中，我们重点关注系统性JIA(SJIA)，它约占英国JIA病例的11%。本研究对IL10基因家族中的3个成员作为sJIA的候选易感基因进行了研究。对473例正常对照和172例sJIA患者的DNA进行了IL19和IL20的单核苷酸多态(SNP)和IL10的两个SNP的基因分型。我们通过单标记和单倍型分析检验了四个SNPs关联的证据。IL 10-1082(p=0.031)和IL 20-468(p=0.028)的等位基因频率在病例组和对照组之间均有显著差异。此外，对IL10-1082和IL20-468单倍型的检测显示了更多的关联证据(全球p=0.0006)。这项研究表明，sJIA患者中低表达IL10-1082基因的患病率显著增加。此外，我们还发现IL20多态和IL10-1082A/IL20-468T单倍型之间存在独立的关联。两个标记‘A-T’单倍型对sJIA的优势比为2.24。这种正相关性表明这些细胞因子在sJIA发病机制中起着重要作用。
Juvenile idiopathic arthritis (JIA) is the most common cause of chronic childhood disability and encompasses a number of disease subgroups. In this study we have focused on systemic JIA (sJIA), which accounts for approximately 11% of UK JIA cases. This study reports the investigation of three members of the IL10 gene family as candidate susceptibility loci in children with sJIA. DNA from 473 unaffected controls and 172 patients with sJIA was genotyped for a single nucleotide polymorphism (SNP) in IL19 and IL20 and two SNPs in IL10. We examined evidence for association of the four SNPs by single marker and haplotype analysis. Significant differences in allele frequency were observed between cases and controls, for both IL10-1082 (p = 0.031) and IL20-468 (p = 0.028). Furthermore, examination of the haplotypes of IL10-1082 and IL20-468 revealed greater evidence for association (global p = 0.0006). This study demonstrates a significant increased prevalence of the low expressing IL10-1082 genotype in patients with sJIA. In addition, we show a separate association with an IL20 polymorphism, and the IL10-1082A/IL20-468T haplotype. The two marker 'A-T' haplotype confers an odds ratio of 2.24 for sJIA. This positive association suggests an important role for these cytokines in sJIA pathogenesis.
登录
查看更多内容
影响因子：
5.5
作者：
Crawley, E;Kon, S;Woo, P
通讯作者：
Woo, P
影响因子：
5.8
作者：
Franchimont, D;Martens, H;Geenen, V
通讯作者：
Geenen, V
影响因子：
2.1
作者：
Dudbridge, F
通讯作者：
Dudbridge, F
影响因子：
15.9
作者：
Fishman, D;Faulds, G;Woo, P
通讯作者：
Woo, P
DOI：
10.1084/jem.20020642
发表时间：
2002-07-15
期刊：
The Journal of experimental medicine
影响因子：
--
作者：
Dieckmann D;Bruett CH;Ploettner H;Lutz MB;Schuler G
通讯作者：
Schuler G