Tissue mimicking material and image artifacts in intravascular elastography
Tissue mimicking material and image artifacts in intravascular elastography
复制标题
血管内弹性成像中的组织模拟材料和图像伪影
DOI：
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发表时间：
1996
期刊：
影响因子：
--
通讯作者：
K. te Nijenhuis
中科院分区：
文献类型：
--
作者：
E. Cespedes;C. D. de Korte;A. V. D. van der Steen;B. Norder;K. te Nijenhuis
血管内超声作为动脉粥样硬化血管局部弹性成像的工具正在研究中：获得压缩模量的图像是最终目标。在实践中，径向应变用于描述局部硬度：这种简化导致必须理解或纠正的伪影。使用琼脂-明胶凝胶构建具有动脉粥样硬化病变的血管模型。研究了这些凝胶的力学性能。使用明胶溶液（8重量%）和可变量的琼脂（1重量%-3重量%）制备具有不同压缩模量的凝胶。使用动态力学分析仪测定模量。模量强烈地依赖于样品的年龄和实际温度。通过改变琼脂浓度，可以实现跨越用于血管体模构造的有用范围的压缩模量。使用体模研究和有限元建模来描述和消除伪影。在简单的形态中，对伪影的补偿是可能的，但是复杂的形态需要复杂的补偿。在这些情况下，有限元方法可以帮助正确解释应变图像的局部组织硬度。
Intravascular ultrasound is being investigated as a tool for imaging the local elasticity of atherosclerotic vessels: obtaining images of the compression modulus is the ultimate goal. In practice, radial strain is used to depict local hardness: this simplification causes artifacts that must be understood or corrected. Phantoms mimicking vessels with atherosclerotic lesions were constructed using agar-gelatin gels. The mechanical properties of these gels were investigated. Gels with varying compression moduli were made using a gelatin solution (8% by weight) with a variable amount of agar (1%-3% by weight). The modulus is determined using a dynamic mechanical analyser. The modulus is strongly dependent on the age and the actual temperature of the samples. By varying the agar concentration, compression moduli spanning a useful range for vascular phantom construction can be achieved. Phantom studies and finite element modelling were used to describe and characterise artifacts. In simple morphologies compensation for the artifacts may be possible, but complex morphologies require complex compensations. In these cases, the finite element method can assist in a correct interpretation of local tissue hardness from strain images.
影响因子：
2.9
作者：
PARKER, KJ;HUANG, SR;LERNER, RM
通讯作者：
LERNER, RM