Microglia influence immune responses and restrict neurologic disease in response to central nervous system infection by a neurotropic murine coronavirus.
Microglia influence immune responses and restrict neurologic disease in response to central nervous system infection by a neurotropic murine coronavirus.
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DOI：
10.3389/fncel.2023.1291255
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发表时间：
2023
影响因子：
5.3
通讯作者：
Lane, Thomas E.
中科院分区：
文献类型：
--
作者：
Syage, Amber;Pachow, Collin;Cheng, Yuting;Mangale, Vrushali;Green, Kim N.;Lane, Thomas E.
颅内（i.c.）用小鼠肝炎病毒（JHMV）的亲胶质株（一种鼠冠状病毒）接种易感小鼠，导致急性脑脊髓炎，随后病毒在白色物质束中持续存在，伴有慢性神经炎症和脱髓鞘。小胶质细胞具有许多功能，包括维持健康的中枢神经系统（CNS），并且是损伤或感染的第一反应者。最近，研究表明，小胶质细胞有助于定制先天性和适应性免疫反应感染后的嗜神经病毒，包括黄病毒，疱疹病毒，和小核糖核酸病毒。这些发现强调了小胶质细胞在宿主防御这些病毒病原体中的重要作用。此外，小胶质细胞在优化CNS内JHMV复制的免疫介导控制同时限制脱髓鞘的严重性和增强髓鞘再生方面也是至关重要的。这篇综述将突出我们目前对小胶质细胞辅助宿主防御、限制神经系统疾病和促进嗜神经性鼠冠状病毒感染后CNS修复的分子和细胞机制的理解。
Intracranial (i.c.) inoculation of susceptible mice with a glial-tropic strain of mouse hepatitis virus (JHMV), a murine coronavirus, results in an acute encephalomyelitis followed by viral persistence in white matter tracts accompanied by chronic neuroinflammation and demyelination. Microglia serve numerous functions including maintenance of the healthy central nervous system (CNS) and are among the first responders to injury or infection. More recently, studies have demonstrated that microglia aid in tailoring innate and adaptive immune responses following infection by neurotropic viruses including flaviviruses, herpesviruses, and picornaviruses. These findings have emphasized an important role for microglia in host defense against these viral pathogens. In addition, microglia are also critical in optimizing immune-mediated control of JHMV replication within the CNS while restricting the severity of demyelination and enhancing remyelination. This review will highlight our current understanding of the molecular and cellular mechanisms by which microglia aid in host defense, limit neurologic disease, and promote repair following CNS infection by a neurotropic murine coronavirus.
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影响因子：
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