Gonococcal lipooligosaccharide sialylation: virulence factor and target for novel immunotherapeutics.
Gonococcal lipooligosaccharide sialylation: virulence factor and target for novel immunotherapeutics.
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淋球菌脂寡糖唾液酸化：毒力因子和新型免疫治疗的靶点。
DOI：
10.1093/femspd/ftx049
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发表时间：
2017
影响因子：
3.3
通讯作者：
Rice,PeterA
中科院分区：
文献类型：
--
作者：
Ram,Sanjay;Shaughnessy,Jutamas;deOliveira,RosaneB;Lewis,LisaA;Gulati,Sunita;Rice,PeterA
Gonorrhea has become resistant to most conventional antimicrobials used in clinical practice. The global spread of multidrug-resistant isolates ofNeisseria gonorrhoeaecould lead to an era of untreatable gonorrhea. New therapeutic modalities with novel mechanisms of action that do not lend themselves to the development of resistance are urgently needed. Gonococcal lipooligosaccharide (LOS) sialylation is critical for complement resistance and for establishing infection in humans and experimental mouse models. Here we describe two immunotherapeutic approaches that target LOS sialic acid: (i) a fusion protein that comprises the region in the complement inhibitor factor H (FH) that binds to sialylated gonococci and IgG Fc (FH/Fc fusion protein) and (ii) analogs of sialic acid that are incorporated into LOS but fail to protect the bacterium against killing. Both molecules showed efficacy in the mouse vaginal colonization model of gonorrhea and may represent promising immunotherapeutic approaches to target multidrug-resistant isolates. Disabling key gonococcal virulence mechanisms is an effective therapeutic strategy because the reduction of virulence is likely to be accompanied by a loss of fitness, rapid elimination by host immunity and consequently, decreased transmission.
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一种新发现的来自阴道加德纳菌的唾液酸酶。
DOI：
10.1016/s0176-6724(84)80003-6
发表时间：
1984
期刊：
Zentralblatt fur Bakteriologie, Mikrobiologie, und Hygiene. Series A, Medical microbiology, infectious diseases, virology, parasitology
影响因子：
--
作者：
H. Von Nicolai;R. Hammann;S. Salehnia;F. Zilliken
通讯作者：
F. Zilliken
通过使用单克隆抗体的全细胞 ELISA 对脑膜炎奈瑟菌进行脂寡糖免疫分型。
影响因子：
3
作者：
Rob J. P. M. Scholten;Betsy Kuipers;Hans A. Valkenburg;Jacob Dankert;W. Zollinger;J. Poolman
通讯作者：
J. Poolman
淋球菌脂寡糖唾液酸化可防止免疫血清的补体依赖性杀伤
影响因子：
3.1
作者：
L M Wetzler;Kevin Barry;M. S. Blake;E. C. Gotschlich
通讯作者：
E. C. Gotschlich
奈瑟菌脂寡糖特异性 α-2,3-唾液酸转移酶是一种表面暴露的外膜蛋白
影响因子：
3.1
作者：
D. Shell;L. Chiles;R. C. Judd;S. Seal;R. Rest
通讯作者：
R. Rest
通过人生殖器分泌物诱导淋球菌对人血清杀伤的表型抗性。
DOI：
10.1136/sti.58.6.363
发表时间：
1982
期刊：
The British Journal of Venereal Diseases
影响因子：
--
作者：
P. Martin;P. Patel;N. Parsons;H. Smith
通讯作者：
H. Smith