A Review on Mesenchymal Stem Cells for Treatment of Retinal Diseases.
A Review on Mesenchymal Stem Cells for Treatment of Retinal Diseases.
复制标题
间充质干细胞治疗视网膜疾病的研究进展
DOI：
10.1007/s12015-020-10090-x
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发表时间：
2021-08
影响因子：
4.8
通讯作者：
Jaganathan BG
中科院分区：
文献类型：
--
作者：
Adak S;Magdalene D;Deshmukh S;Das D;Jaganathan BG
间充质干细胞（MSC）已被广泛研究用于治疗几种视网膜疾病。骨髓间充质干细胞的治疗潜力在于其分化为多个谱系和富含免疫调节、抗血管生成和神经营养因子的分泌体的能力。一些研究已经报道了MSC在受损视网膜的修复和再生中的作用，其中来自MSC的分泌因子防止视网膜变性，改善视网膜形态和功能。MSC还捐献线粒体以拯救视网膜细胞的功能，并且发现MSC分泌的外泌体具有抗凋亡和抗炎作用。基于从临床前研究中获得的几个有希望的结果，启动了几项临床试验以探索MSC用于治疗视网膜疾病的潜在优势。本文综述了骨髓间充质干细胞的各种特性，有助于修复和恢复受损的视网膜细胞及其治疗视网膜退行性疾病的潜力。
Mesenchymal Stem Cells (MSCs) have been studied extensively for the treatment of several retinal diseases. The therapeutic potential of MSCs lies in its ability to differentiate into multiple lineages and secretome enriched with immunomodulatory, anti-angiogenic and neurotrophic factors. Several studies have reported the role of MSCs in repair and regeneration of the damaged retina where the secreted factors from MSCs prevent retinal degeneration, improve retinal morphology and function. MSCs also donate mitochondria to rescue the function of retinal cells and exosomes secreted by MSCs were found to have anti-apoptotic and anti-inflammatory effects. Based on several promising results obtained from the preclinical studies, several clinical trials were initiated to explore the potential advantages of MSCs for the treatment of retinal diseases. This review summarizes the various properties of MSCs that help to repair and restore the damaged retinal cells and its potential for the treatment of retinal degenerative diseases.
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