Clinical pharmacology of 3'-azido-2',3'-dideoxythymidine (zidovudine) and related dideoxynucleosides.

Clinical pharmacology of 3'-azido-2',3'-dideoxythymidine (zidovudine) and related dideoxynucleosides.
复制标题

3-叠氮基-2,3-二脱氧胸苷(齐多夫定)和相关双脱氧核苷的临床药理学。

DOI:
--
复制
发表时间:
1989
影响因子:
158.5
通讯作者:
S. Broder
S. Broder
中科院分区:
医学1区
文献类型:
--
作者:
R. Yarchoan;H. Mitsuya;C. Myers;S. Broder

文献摘要

参考文献

被引文献

相似文献

由于发现了一种细胞病态逆转录病毒,现在称为人类免疫缺陷病毒(HIV),导致了这种疾病,从而有可能开发出针对获得性免疫缺陷综合征(AIDS)病原体的合理治疗方法。4 5 6这一发现和大规模培养病毒的能力使体外技术的发展成为可能,以找到抑制艾滋病毒复制的药物。7、8.在体外确定了8种在体外对艾滋病毒起作用的物质,从而继续进行药物的实际开发。这项工作在一定程度上是中国早期对动物逆转录病毒系统研究的成果。
THE development of a rational therapy against the etiologic agent of the acquired immunodeficiency syndrome (AIDS)1 2 3 was made possible by the discovery that a cytopathic retrovirus, now called the human immunodeficiency virus (HIV), caused the disorder.4 5 6 This discovery and the ability to grow the virus in large quantities made possible the development of in vitro techniques to find drugs that inhibit the replication of HIV.7 , 8 Substances that acted against HIV in vitro were identified for further study, and the practical development of drugs thus proceeded. The work was in part an outgrowth of early research on animal retroviral systems in . . .
DOI: 10.1126/science.2830675
发表时间: 1988-03
期刊: Science
影响因子: 56.9
作者:
Gary J. Nabel;Stephen A. Rice;D. Knipe;D. Baltimore
通讯作者: Gary J. Nabel;Stephen A. Rice;D. Knipe;D. Baltimore
DOI: --
发表时间: 1987
期刊: The Journal of biological chemistry
影响因子: --
作者:
Cheng,YC;Dutschman,GE;Bastow,KF;Sarngadharan,MG;Ting,RY
通讯作者: Ting,RY
2,3-二脱氧胞苷的细胞代谢,一种在体外具有抗人类免疫缺陷病毒活性的化合物。
DOI: --
发表时间: 1987
期刊: The Journal of biological chemistry
影响因子: --
作者:
Starnes,MC;Cheng,YC
通讯作者: Cheng,YC
HIV 感染的细胞被 rCD4-蓖麻毒素 A 链杀死。
DOI: 10.1126/science.2847316
发表时间: 1988
期刊: Science (New York, N.Y.)
影响因子: --
作者:
Till,MA;Ghetie,V;Gregory,T;Patzer,EJ;Porter,JP;Uhr,JW;Capon,DJ;Vitetta,ES
通讯作者: Vitetta,ES
DOI: 10.1126/science.2467383
发表时间: 1989-03-31
期刊: SCIENCE
影响因子: 56.9
作者:
LARDER, BA;DARBY, G;RICHMAN, DD
通讯作者: RICHMAN, DD