Challenges in translational research: the views of addiction scientists.
Challenges in translational research: the views of addiction scientists.
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DOI：
10.1371/journal.pone.0093482
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发表时间：
2014
期刊：
影响因子：
3.7
通讯作者：
McCormick JB
中科院分区：
文献类型：
--
作者：
Ostergren JE;Hammer RR;Dingel MJ;Koenig BA;McCormick JB
探索科学家对将研究成果转化为临床实践和公共卫生政策的挑战和压力的观点。我们对20位从事成瘾基因研究的顶尖科学家进行了半结构化访谈。我们向参与者询问了他们对自己的研究如何转化的看法，基因研究如何将成瘾作为一个公共卫生问题来解决，以及它如何影响公众对成瘾的看法。大多数科学家描述了他们的研究的直接转化途径，假设他们的研究将具有显著的社会效益，导致治疗和新的预防策略的进步。然而，科学家们也指出，他们感受到将研究成果迅速转化为实际临床或公共卫生用途的内在压力。他们强调了让科学过程发挥作用的重要性，对最近加快翻译速度的努力表达了矛盾的态度。人们对生物医学将带来新的预防和治疗方式寄予了很高的期望，这给科学家带来了压力。我们的数据表明，科学家们觉得自己被立即应用的压力所困住了。过分强调快速转化可能导致技术和应用在没有对伦理、政策和社会影响进行批判性评估的情况下匆忙投入使用，也没有将其价值与现有的公共卫生政策和干预措施进行平衡。
To explore scientists' perspectives on the challenges and pressures of translating research findings into clinical practice and public health policy. We conducted semi-structured interviews with a purposive sample of 20 leading scientists engaged in genetic research on addiction. We asked participants for their views on how their own research translates, how genetic research addresses addiction as a public health problem and how it may affect the public's view of addiction. Most scientists described a direct translational route for their research, positing that their research will have significant societal benefits, leading to advances in treatment and novel prevention strategies. However, scientists also pointed to the inherent pressures they feel to quickly translate their research findings into actual clinical or public health use. They stressed the importance of allowing the scientific process to play out, voicing ambivalence about the recent push to speed translation. High expectations have been raised that biomedical science will lead to new prevention and treatment modalities, exerting pressure on scientists. Our data suggest that scientists feel caught in the push for immediate applications. This overemphasis on rapid translation can lead to technologies and applications being rushed into use without critical evaluation of ethical, policy, and social implications, and without balancing their value compared to public health policies and interventions currently in place.
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成瘾和大脑奖励和反发达途径。
影响因子：
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作者：
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通讯作者：
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影响因子：
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作者：
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DOI：
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发表时间：
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期刊：
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作者：
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作者：
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影响因子：
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