A fluid mechanical analysis of the velocity, adhesion, and destruction of cancer cells in capillaries during metastasis
A fluid mechanical analysis of the velocity, adhesion, and destruction of cancer cells in capillaries during metastasis
复制标题
对转移过程中毛细血管中癌细胞的速度、粘附和破坏进行流体力学分析
DOI：
10.1007/bf02788577
复制
发表时间：
1984
期刊：
影响因子：
--
通讯作者：
D. S. Dimitrov
中科院分区：
文献类型：
--
作者：
L. Weiss;D. S. Dimitrov
转移是一个多步骤的过程，癌症主要通过血管内途径在体内扩散，是癌症的主要问题。当癌细胞直接注射到动物静脉中时，它们显然被捕获在第一个器官的血管床中，并在接下来的24小时内逐渐释放。这些与微血管系统的相互作用通常以某种方式与许多癌细胞的死亡有关，并被认为是导致转移过程无效的原因。我们从癌细胞变形为毛细血管的血管内速度、与血管内皮的粘附和血管内破坏方面进行了理论分析，根据分离血管和癌细胞表面的薄液膜的动力学。我们的计算是基于以前报道的实验观察，表明癌细胞通过微血管的运输是不连续的，被两者之间的粘连所打断。此外，本发明还提供了一种方法，在某些情况下细胞膜破裂（细胞死亡）当癌细胞膜的临界张力超过其初始平衡膜张力和癌细胞膜在毛细血管管腔内表面上运动时产生的摩擦引起的增加的张力的总和时，膜破裂将发生。我们对膜破裂的计算与Sato和Suzuki以前未解释的观察结果一致将癌细胞变形性与经骨髓通道的死亡联系起来，并构成了血管内癌细胞死亡方面的“转移无效”的新机制。
Metastasis, a multistep process by which cancer disseminates through the body, mainly by intravascular routes, constitutes a major problem in cancer.When cancer cells are injected directly into the veins of animals, they are apparently arrested in the vascular bed of the first organ encountered and gradually released over the next 24 h. These interactions with the microvasculature are often associated in some manner with the death of many cancer cells, and are thought to contribute to the inefficiency of the metastatic process.We have made a theoretical analysis of cancer cells deformed into capillaries with respect to their intravascular velocity, adhesion to the vascular endothelium and intravascular destruction, in terms of the dynamics of the thin liquid film separating the surfaces of the blood vessels and cancer cells.Our calculations, which are based on previously reported experimental observations, indicate that the transit of cancer cells through the microvasculature is discontinuous, being interrupted by adhesions between the two. In addition, in some cases cell membrane rupture (and cell death) will occur when the critical membrane tension of the cancer cells is exceeded by the sum of their initial equilibrium membrane tension and the increased tension in the cancer cell membranes caused by friction generated as they move over the intraluminal surfaces of the capillaries.Our calculations on membrane rupture are consistent with previously unexplained observations by Sato and Suzuki relating cancer cell deformability to death on transpulmonary passage, and constitute a novel mechanism for “metastatic inefficiency” in terms of intravascular cancer cell death.
影响因子：
8.8
作者：
Weiss, L;Mayhew, E;Rapp, D G;Holmes, J C
通讯作者：
Holmes, J C