Intestinal epithelial autophagy is essential for host defense against invasive bacteria.
Intestinal epithelial autophagy is essential for host defense against invasive bacteria.
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DOI：
10.1016/j.chom.2013.05.004
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发表时间：
2013-06-12
影响因子：
30.3
通讯作者：
Hooper LV
中科院分区：
文献类型：
--
作者：
Benjamin JL;Sumpter R Jr;Levine B;Hooper LV
哺乳动物的肠道内定植着多种多样的细菌群落，这些细菌具有许多有益的功能，但在组织侵入时会威胁宿主的健康。上皮细胞固有的先天性免疫反应是必不可少的，以限制入侵的肠道和致病性细菌，并保持有益的宿主-细菌的关系，然而，鲜为人知的各种细胞过程中的作用，特别是自噬，在体内控制细菌与肠上皮细胞的相互作用。我们证明，肠上皮细胞自噬保护免受组织入侵的机会性侵入性细菌和入侵性肠道病原体，鼠伤寒沙门氏菌。自噬在细菌侵入上皮细胞后通过需要上皮细胞内在信号传导的过程被激活，该信号传导经由先天免疫适配蛋白MyD 88。此外，肠上皮细胞自噬缺陷的小鼠表现出侵袭性细菌向肠外部位的传播增加。因此，自噬是一种重要的上皮细胞自主抗菌防御机制，可以防止肠道细菌的传播。
The mammalian intestine is colonized with a diverse community of bacteria that perform many beneficial functions but can threaten host health upon tissue invasion. Epithelial cell-intrinsic innate immune responses are essential to limit the invasion of both commensal and pathogenic bacteria and maintain beneficial host-bacterial relationships; however, little is known about the role of various cellular processes, notably autophagy, in controlling bacterial interactions with the intestinal epithelium in vivo. We demonstrate that intestinal epithelial cell autophagy protects against tissue invasion by both opportunistically invasive commensals and the invasive intestinal pathogen, Salmonella typhimurium. Autophagy is activated following bacterial invasion of epithelial cells through a process requiring epithelial cell-intrinsic signaling via the innate immune adaptor protein MyD88. Additionally, mice deficient in intestinal epithelial cell autophagy exhibit increased dissemination of invasive bacteria to extraintestinal sites. Thus, autophagy is an important epithelial cell-autonomous mechanism of antibacterial defense that protects against dissemination of intestinal bacteria.
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影响因子：
32.4
作者：
Hou, Baidong;Reizis, Boris;DeFranco, Anthony L.
通讯作者：
DeFranco, Anthony L.
影响因子：
30.8
作者：
Hampe, Jochen;Franke, Andre;Schreiber, Stefan
通讯作者：
Schreiber, Stefan
影响因子：
29.4
作者：
Homer CR;Richmond AL;Rebert NA;Achkar JP;McDonald C
通讯作者：
McDonald C
影响因子：
64.5
作者：
Cadwell K;Patel KK;Maloney NS;Liu TC;Ng AC;Storer CE;Head RD;Xavier R;Stappenbeck TS;Virgin HW
通讯作者：
Virgin HW
DOI：
10.1083/jcb.152.3.519
发表时间：
2001-02-05
期刊：
The Journal of cell biology
影响因子：
--
作者：
Kihara A;Noda T;Ishihara N;Ohsumi Y
通讯作者：
Ohsumi Y