Timing of peripubertal steroid exposure predicts visuospatial cognition in men: Evidence from three samples.
Timing of peripubertal steroid exposure predicts visuospatial cognition in men: Evidence from three samples.
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DOI：
10.1016/j.yhbeh.2020.104712
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发表时间：
2020-05
影响因子：
3.5
通讯作者：
Puts D
中科院分区：
文献类型：
--
作者：
Shirazi TN;Self H;Cantor J;Dawood K;Cárdenas R;Rosenfield K;Ortiz T;Carré J;McDaniel MA;Blanchard R;Balasubramanian R;Delaney A;Crowley W;Breedlove SM;Puts D
在雄性啮齿类动物中的实验表明，对类固醇激素的组织效应的敏感性在青春期窗口期间降低，早期雄激素暴露导致大脑和行为的更大男性化。同样，一些研究表明，青春期暴露于性类固醇的时间会影响人类心理的各个方面，包括视觉空间认知。然而，先前的研究受到样本量小和/或青春期时间测量不精确的限制。我们进行了4项研究，以澄清青春期激素暴露的时间是否预测成年后男性空间认知测试的表现。在研究1（n = 1095）和2（n = 173）中，我们调查了回忆青春期年龄和典型发育男性的空间认知之间的关联，控制了研究2中当前的睾酮水平。在研究3（n = 51）中，我们研究了空间性能和年龄之间的关系，在青春期激素替代治疗开始在一个样本的男性与孤立的GnRH缺乏症。在研究1-3中，空间表现和青春期时间之间关系的效应量估计值范围为。-0.04和-0.27，在研究2中，空间表现与唾液睾酮无关。在研究4中，我们对研究1-3和4项先前发表的研究进行了两项荟萃分析。第一个荟萃分析进行了空间性能和青春期绝对年龄的时间测量之间的相关性，第二个取代空间性能和相对青春期时间的措施之间的相关性。在第一次和第二次荟萃分析中，青春期时间和空间认知之间相关性的点估计值分别为-0.15和-0.12（均为p < 0.001）。这些关联在排除任何个体研究的情况下都是稳健的。我们的研究结果表明，在神经发育的某些方面，对性腺激素的敏感性在整个青春期下降，青春期激素暴露越早，成年期心理表型的性别典型性越大。这些结果揭示了行为和大脑组织的过程，并对IGD和其他青春期时间被人为操纵的疾病的治疗有影响。
Experiments in male rodents demonstrate that sensitivity to the organizational effects of steroid hormones decreases across the pubertal window, with earlier androgen exposure leading to greater masculinization of the brain and behavior. Similarly, some research suggests the timing of peripubertal exposure to sex steroids influences aspects of human psychology, including visuospatial cognition. However, prior studies have been limited by small samples and/or imprecise measures of pubertal timing. We conducted 4 studies to clarify whether the timing of peripubertal hormone exposure predicts performance on male-typed tests of spatial cognition in adulthood. In Studies 1 (n = 1095) and 2 (n = 173), we investigated associations between recalled pubertal age and spatial cognition in typically developing men, controlling for current testosterone levels in Study 2. In Study 3 (n = 51), we examined the relationship between spatial performance and the age at which peripubertal hormone replacement therapy was initiated in a sample of men with Isolated GnRH Deficiency. Across Studies 1–3, effect size estimates for the relationship between spatial performance and pubertal timing ranged from. −0.04 and −0.27, and spatial performance was unrelated to salivary testosterone in Study 2. In Study 4, we conducted two meta-analyses of Studies 1–3 and four previously published studies. The first meta-analysis was conducted on correlations between spatial performance and measures of the absolute age of pubertal timing, and the second replaced those correlations with correlations between spatial performance and measures of relative pubertal timing where available. Point estimates for correlations between pubertal timing and spatial cognition were −0.15 and −0.12 (both p < 0.001) in the first and second meta-analyses, respectively. These associations were robust to the exclusion of any individual study. Our results suggest that, for some aspects of neural development, sensitivity to gonadal hormones declines across puberty, with earlier pubertal hormone exposure predicting greater sex-typicality in psychological phenotypes in adulthood. These results shed light on the processes of behavioral and brain organization and have implications for the treatment of IGD and other conditions wherein pubertal timing is pharmacologically manipulated.
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影响因子：
3.5
作者：
Beltz, Adriene M.;Berenbaum, Sheri A.
通讯作者：
Berenbaum, Sheri A.
影响因子：
158.5
作者：
COMITE, F;CUTLER, GB;CROWLEY, WF
通讯作者：
CROWLEY, WF
影响因子：
2.7
作者：
Bischof, HJ;Rollenhagen, A
通讯作者：
Rollenhagen, A
焦虑和抑郁症临床观点的性别差异。
影响因子：
7.4
作者：
Altemus M;Sarvaiya N;Neill Epperson C
通讯作者：
Neill Epperson C
DOI：
10.1176/appi.ajp.2010.09081190
发表时间：
2010-10
期刊：
The American journal of psychiatry
影响因子：
--
作者：
Copeland W;Shanahan L;Miller S;Costello EJ;Angold A;Maughan B
通讯作者：
Maughan B