Muscle Atrophy Induced by Mechanical Unloading: Mechanisms and Potential Countermeasures.
Muscle Atrophy Induced by Mechanical Unloading: Mechanisms and Potential Countermeasures.
复制标题
机械卸载引起的肌肉萎缩：机制和潜在对策
DOI：
10.3389/fphys.2018.00235
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发表时间：
2018
影响因子：
4
通讯作者：
Goswami N
中科院分区：
文献类型：
--
作者：
Gao Y;Arfat Y;Wang H;Goswami N
长时间的骨骼肌不活动或机械卸载（卧床休息，后肢卸载，固定，航天和减少步骤）可导致肌肉骨骼质量，大小和强度的显着损失，最终导致肌肉萎缩。随着对废用性骨骼肌萎缩的分子和细胞机制的了解的进展，已经研究了几种不同的信号通路以了解它们在这个过程中的调节作用。然而，在我们对所涉及的监管机制及其功能意义的理解方面存在着巨大的差距。这篇综述的目的是更新目前的知识状态和相关的骨骼肌损失在各种卸载条件下，在人类和动物的细胞机制。强调了细胞和分子机制的最新进展，包括IGF1-Akt-mTOR，MuRF1/MAFbx，FOXO和废用性萎缩的潜在触发因素，如钙超载和ROS过量产生，以及它们在骨骼肌蛋白适应废用中的作用。我们还阐述了潜在的治疗对策，在预防和恢复废用性肌肉损失方面显示出有希望的结果。最后，指出了该领域的主要挑战以及未来的展望。
Prolonged periods of skeletal muscle inactivity or mechanical unloading (bed rest, hindlimb unloading, immobilization, spaceflight and reduced step) can result in a significant loss of musculoskeletal mass, size and strength which ultimately lead to muscle atrophy. With advancement in understanding of the molecular and cellular mechanisms involved in disuse skeletal muscle atrophy, several different signaling pathways have been studied to understand their regulatory role in this process. However, substantial gaps exist in our understanding of the regulatory mechanisms involved, as well as their functional significance. This review aims to update the current state of knowledge and the underlying cellular mechanisms related to skeletal muscle loss during a variety of unloading conditions, both in humans and animals. Recent advancements in understanding of cellular and molecular mechanisms, including IGF1-Akt-mTOR, MuRF1/MAFbx, FOXO, and potential triggers of disuse atrophy, such as calcium overload and ROS overproduction, as well as their role in skeletal muscle protein adaptation to disuse is emphasized. We have also elaborated potential therapeutic countermeasures that have shown promising results in preventing and restoring disuse-induced muscle loss. Finally, identified are the key challenges in this field as well as some future prospectives.
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DOI：
10.1097/00005768-200010000-00013
发表时间：
2000-10-01
期刊：
MEDICINE AND SCIENCE IN SPORTS AND EXERCISE
影响因子：
--
作者：
Akima, H;Kawakami, Y;Fukunaga, T
通讯作者：
Fukunaga, T
影响因子：
3.3
作者：
Baehr, Leslie M.;West, Daniel W. D.;Bodine, Sue C.
通讯作者：
Bodine, Sue C.
影响因子：
3.9
作者：
Bechsoft, Rasmus Leidesdorff;Malmgaard-Clausen, Nikolaj Molkjaer;Holm, Lars
通讯作者：
Holm, Lars
影响因子：
4.2
作者：
Anthony, JC;Anthony, TG;Jefferson, LS
通讯作者：
Jefferson, LS
影响因子：
3
作者：
Bajotto, Gustavo;Sato, Yuzo;Shimomura, Yoshiharu
通讯作者：
Shimomura, Yoshiharu