Multi-Replicated Enrichment Communities as a Model System in Microbial Ecology.

Multi-Replicated Enrichment Communities as a Model System in Microbial Ecology.
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DOI:
10.3389/fmicb.2021.657467
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发表时间:
2021
影响因子:
5.2
通讯作者:
Rebolleda-Gómez M
Rebolleda-Gómez M
中科院分区:
生物学2区
文献类型:
--
作者:
Estrela S;Sánchez Á;Rebolleda-Gómez M

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机器人技术和负担得起的基因组测序技术的最新进展使得有可能以高通量建立和定量跟踪富集社区的组装。通过在多达数千个合成栖息地中进行群落组装实验,可以控制重复之间的外部变异来源,我们现在可以研究不同组织水平下微生物群落组装的可重复性和可预测性,以及其与营养成分和其他生态驱动因素的关系。通过与数学模型的对话,高通量富集社区使我们更接近开发微生物群落组装的定量预测理论的目标。在这篇简短的综述中,我们概述了这一不断发展的领域的最新研究,强调了理论和实验之间的联系,并提出了未来工作的方向。
Recent advances in robotics and affordable genomic sequencing technologies have made it possible to establish and quantitatively track the assembly of enrichment communities in high-throughput. By conducting community assembly experiments in up to thousands of synthetic habitats, where the extrinsic sources of variation among replicates can be controlled, we can now study the reproducibility and predictability of microbial community assembly at different levels of organization, and its relationship with nutrient composition and other ecological drivers. Through a dialog with mathematical models, high-throughput enrichment communities are bringing us closer to the goal of developing a quantitative predictive theory of microbial community assembly. In this short review, we present an overview of recent research on this growing field, highlighting the connection between theory and experiments and suggesting directions for future work.
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