Multimodal imaging of nano-assembled microspheres loaded with doxorubicin and Cisplatin for liver tumor therapy.
Multimodal imaging of nano-assembled microspheres loaded with doxorubicin and Cisplatin for liver tumor therapy.
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负载阿霉素和顺铂的纳米组装微球用于肝脏肿瘤治疗的多模态成像
DOI：
10.3389/fbioe.2022.1024174
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发表时间：
2022
影响因子：
5.7
通讯作者：
Shao, Guoliang
中科院分区：
文献类型：
--
作者：
He, Yiwei;Zhang, Yuqing;Gong, Yuanchuan;Zhang, Zhewei;Xu, Tiancheng;Tian, Liqiang;Pan, Ting;Yang, Hong;Pan, Hao;Kou, Quanming;Wang, Hao;Shao, Guoliang
目前，临床上可用的载药栓子微球存在一些缺点，如标准医学成像方式不可见，只能携带带正电的药物。载药微球的可视化对栓塞位置的实时监测，提高治疗效果具有重要意义。同时，微球可视化可以方便术后复查，有助于评估栓塞面积，指导后续治疗。此外，微球能够装载不同的带电药物，可以增加化疗药物的选择，为治疗提供更多的可能性。因此，探索能够多模态显像、装载不同电荷药物的载药微球对于肝肿瘤经动脉化疗栓塞（TACE）治疗具有重要意义。在我们的研究中，我们设计了一种纳米组装微球（NAMs），可以实现计算机x射线断层扫描(CT)/磁共振成像(MRI)/拉曼多模态成像，装载带正电荷和负电荷的药物，并测试其成像能力、载药量和生物安全性。微球对CT具有较强的衰减性能，对MRI具有较高的T2弛豫性能，对表面增强拉曼光谱（SERS）具有良好的灵敏度。同时，我们的微球还可以装载带正电荷的药物阿霉素（DOX）和带负电荷的药物顺铂。1克NAMs可容纳168 mg DOX或126 mg顺铂，具有良好的载药和缓释能力。细胞实验也表明，纳米组装微球具有良好的生物相容性。因此，作为多模态开发的载药微球，纳米组装微球在肝癌TACE治疗中具有很大的潜力。
Currently, clinically available drug-loaded embolic microspheres have some shortcomings, such as being invisible with standard medical imaging modalities and only being able to carry positively charged drugs. The visualization of drug-loaded microspheres is very important for real-time monitoring of embolic position to improve the therapeutic effect. Meanwhile, the visualization of microspheres can enable postoperative reexamination, which is helpful for evaluating the embolization area and guiding the subsequent treatment. In addition, microspheres capable of loading different charged drugs can increase the choice of chemotherapeutic drugs and provide more possibilities for treatment. Therefore, it is of great importance to explore drug-loaded microspheres capable of multimodal imaging and loading drugs with different charges for transarterial chemoembolization (TACE) treatment of liver tumors. In our study, we designed a kind of nano-assembled microspheres (NAMs) that can realize computer X-ray tomography (CT)/magnetic resonance imaging (MRI)/Raman multimodal imaging, be loaded with positively and negatively charged drugs and test their imaging ability, drug loading and biological safety. The microspheres have strong attenuation performance for CT, high T2 relaxation for MRI and good sensitivity for surface enhanced Raman spectroscopy (SERS). At the same time, our microspheres can also load the positively charged drug, doxorubicin (DOX), and negatively charged drug Cisplatin. One gram of NAMs can hold 168 mg DOX or 126 mg Cisplatin, which has good drug loading and sustained-release capacity. Cell experiments also showed that the nano-assembled microspheres had good biocompatibility. Therefore, as multimodal developed drug loaded microspheres, nano assembled microspheres have great potential in TACE treatment of liver cancer.
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DOI：
10.1016/j.jconrel.2017.02.001
发表时间：
2017-03-28
期刊：
Journal of controlled release : official journal of the Controlled Release Society
影响因子：
--
作者：
Ashrafi K;Tang Y;Britton H;Domenge O;Blino D;Bushby AJ;Shuturminska K;den Hartog M;Radaelli A;Negussie AH;Mikhail AS;Woods DL;Krishnasamy V;Levy EB;Wood BJ;Willis SL;Dreher MR;Lewis AL
通讯作者：
Lewis AL
影响因子：
2.9
作者：
Dreher, Matthew R.;Sharma, Karun V.;Woods, David L.;Reddy, Goutham;Tang, Yiqing;Pritchard, William F.;Chiesa, Oscar A.;Karanian, John W.;Esparza, Juan A.;Donahue, Danielle;Levy, Elliot B.;Willis, Sean L.;Lewis, Andrew L.;Wood, Bradford J.
通讯作者：
Wood, Bradford J.
影响因子：
6.2
作者：
Hagit, Aviv;Soenke, Bartling;Shlomo, Margel
通讯作者：
Shlomo, Margel
影响因子：
5.2
作者：
Vogl TJ;Lahrsow M
通讯作者：
Lahrsow M
影响因子：
8.6
作者：
Jana, NR;Gearheart, L;Murphy, CJ
通讯作者：
Murphy, CJ