A critical period for social experience-dependent oligodendrocyte maturation and myelination.
A critical period for social experience-dependent oligodendrocyte maturation and myelination.
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DOI：
10.1126/science.1220845
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发表时间：
2012-09-14
期刊：
影响因子：
--
通讯作者：
Corfas G
中科院分区：
文献类型：
--
作者：
Makinodan M;Rosen KM;Ito S;Corfas G
早期的社会隔离导致成年后的行为和认知功能障碍，这与白色物质的改变有关。然而，社会剥夺如何影响髓鞘形成以及这些髓鞘缺陷在成人中的意义仍然不明确。我们发现，断奶后立即隔离2周的小鼠在前额叶皮层功能和髓鞘形成方面发生了改变，这些改变不会随着重新引入社会环境而恢复。这些变化仅发生在这个关键时期，通过少突胶质细胞ErbB 3受体的丧失而表现出来，而社会隔离导致ErbB 3配体神经调节素-1的表达减少。这些发现表明，社会经验通过neuregulin-1/ErbB 3信号调节前额叶皮层髓鞘形成，这对正常的认知功能至关重要，从而为理解社会隔离的后果提供了细胞和分子背景。
Early social isolation results in adult behavioral and cognitive dysfunction that correlates with white matter alterations. However, how social deprivation influences myelination and the significance of these myelin defects in the adult remained undefined. We show that mice isolated for 2 weeks immediately after weaning have alterations in prefrontal cortex function and myelination that do not recover with reintroduction into a social environment. These alterations, which occur only during this critical period, are phenocopied by loss of oligodendrocyte ErbB3 receptors, and social isolation leads to reduced expression of the ErbB3 ligand neuregulin-1. These findings indicate that social experience regulates prefrontal cortex myelination through neuregulin-1/ErbB3 signaling and that this is essential for normal cognitive function, thus providing a cellular and molecular context to understand the consequences of social isolation.
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影响因子：
16.2
作者：
Brinkmann, Bastian G.;Agarwal, Amit;Sereda, Michael W.;Garratt, Alistair N.;Mueller, Thomas;Wende, Hagen;Stassart, Ruth M.;Nawaz, Schanila;Humml, Christian;Velanac, Viktorija;Radyushkin, Konstantin;Goebbels, Sandra;Fischer, Tobias M.;Franklin, Robin J.;Lai, Cary;Ehrenreich, Hannelore;Birchmeier, Carmen;Schwab, Markus H.;Nave, Klaus Armin
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Nave, Klaus Armin
影响因子：
3.8
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Buonanno A
影响因子：
16.2
作者：
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通讯作者：
Salzer, JL
影响因子：
1.5
作者：
Doerflinger, NH;Macklin, WB;Popko, B
通讯作者：
Popko, B
影响因子：
3.4
作者：
Dias, R;Aggleton, JP
通讯作者：
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