Monitoring proton radiation therapy with in-room PET imaging.
Monitoring proton radiation therapy with in-room PET imaging.
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DOI：
10.1088/0031-9155/56/13/019
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发表时间：
2011-07-07
影响因子：
3.5
通讯作者：
El Fakhri G
中科院分区：
文献类型：
--
作者：
Zhu X;España S;Daartz J;Liebsch N;Ouyang J;Paganetti H;Bortfeld TR;El Fakhri G
我们使用位于质子治疗治疗室内的移动PET扫描仪来研究室内独立PET系统验证质子范围的可行性，并与离线等效研究进行比较。两名患有腺样囊性癌的受试者被纳入一项初步研究，在常规分级治疗后，以列表模式获得室内PET扫描。用不同的时间方案重构列表模式PET数据，生成室内短、室内长和离线等效（在列表模式重构过程中跳过前15分钟的重合）PET图像，以比较活动分布模式。通过模拟实验，定量评价了不同重建时间方案下距离验证的准确性。与离线方式相比，室内PET具有更高的灵敏度，因此PET采集时间可以从30分钟大大缩短到<5分钟。由于15O成分的收集和较低的生物冲洗，室内短PET采集的深部软组织区域的特征得到了更好的保留。对于软组织等效材料，与离线等效扫描相比，室内短采集的远端脱落边缘更深，表明光束的高剂量端覆盖更好。室内PET是一种很有前途的低成本、高灵敏度的质子治疗体内验证方式。提高蒙特卡罗预测的准确性，特别是对生物衰变建模，是必要的。
We used a mobile PET scanner positioned within the proton therapy treatment room to study the feasibility of proton range verification with an in-room, stand-alone PET system, and compared with off-line equivalent studies. Two subjects with adenoid cystic carcinoma were enrolled into a pilot study in which in-room PET scans were acquired in list-mode after a routine fractionated treatment session. The list-mode PET data were reconstructed with different time schemes to generate in-room short, in-room long and off-line equivalent (by skipping coincidences from the first 15 minutes during the list-mode reconstruction) PET images for comparison in activity distribution patterns. A phantom study was followed to evaluate the accuracy of range verification for different reconstruction time schemes quantitatively. The in-room PET has a higher sensitivity compared to the off-line modality so that the PET acquisition time can be greatly reduced from 30 min to <5 min. Features in deep-site, soft-tissue regions were better retained with in-room short PET acquisitions because of the collection of 15O component and lower biological washout. For soft tissue-equivalent material, the distal fall-off edge of an in-room short acquisition is deeper compared to an off-line equivalent scan, indicating a better coverage of the high-dose end of the beam. In-room PET is a promising low cost, high sensitivity modality for the in vivo verification of proton therapy. Better accuracy in Monte Carlo predictions, especially for biological decay modeling, is necessary.
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影响因子：
3.5
作者：
Knopf, A.;Parodi, K.;Paganetti, H.
通讯作者：
Paganetti, H.
影响因子：
3.5
作者：
Knopf, A.;Parodi, K.;Bortfeld, T.
通讯作者：
Bortfeld, T.
影响因子：
1.8
作者：
Pawelke, J;Enghardt, W;Sobiella, M
通讯作者：
Sobiella, M
DOI：
10.1016/j.ijrobp.2008.02.033
发表时间：
2008-07-01
影响因子：
7
作者：
Parodi, Katia;Bortfeld, Thomas;Haberer, Thomas
通讯作者：
Haberer, Thomas
影响因子：
3.5
作者：
Paganetti, Harald;Jiang, Hongyu;Engelsman, Martijn
通讯作者：
Engelsman, Martijn