Methapyrilene is inactive in the hepatocyte-mediated Chinese hamster ovary/hypoxanthine-guanine phosphoribosyl transferase mutational assay.
Methapyrilene is inactive in the hepatocyte-mediated Chinese hamster ovary/hypoxanthine-guanine phosphoribosyl transferase mutational assay.
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甲基吡林在肝细胞介导的中国仓鼠卵巢/次黄嘌呤-鸟嘌呤磷酸核糖转移酶突变测定中无活性。
DOI：
10.1016/0304-3835(84)90014-4
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发表时间：
1984
期刊：
影响因子：
9.7
通讯作者：
H. Schol
中科院分区：
文献类型：
--
作者：
D. Casciano;H. Schol
在肝细胞介导的中国仓鼠卵巢/次黄嘌呤-鸟嘌呤磷酸核糖转移酶（HGPRT）突变试验中，在非肝细胞毒性和肝细胞毒性浓度下检测的Methapyrilene未能诱导体细胞突变。这些数据支持以下结论：美沙吡林通过非DNA损伤机制诱导致癌过程，这表明该抗组胺药之前在为检测致癌物和诱变剂而开发的几种体外试验系统中未能诱导遗传毒性反应。
Methapyrilene, tested at both non-hepatocytotoxic and hepatocytotoxic concentrations, failed to induce somatic mutations in the hepatocyte-mediated Chinese hamster ovary/hypoxanthine-guanine phosphoribosyl transferase (HGPRT) mutational assay. These data support the conclusion that methapyrilene induces the carcinogenesis process through a non-DNA damaging mechanism, suggested when this antihistamine previously failed to induce a genotoxic response in several in vitro test systems developed to detect carcinogens and mutagens.
通过预先施用 N-2-芴基乙酰胺，增强抗组胺药物甲吡林对大鼠肝癌发生的作用。
影响因子：
3.8
作者：
Furuya,K;Mori,H;Williams,GM
通讯作者：
Williams,GM