Decreased expression of C10orf10 and its prognostic significance in human breast cancer.
Decreased expression of C10orf10 and its prognostic significance in human breast cancer.
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C10orf10 在人类乳腺癌中的表达降低及其预后意义
DOI：
10.1371/journal.pone.0099730
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发表时间：
2014
期刊：
影响因子：
3.7
通讯作者：
Li J
中科院分区：
文献类型：
--
作者：
Deng J;Dong Y;Li C;Zuo W;Meng G;Xu C;Li J
乳腺癌是一种常见的恶性肿瘤，严重威胁着妇女的健康，在许多国家的发病率呈上升趋势。在这里，我们确定了C10 orf 10作为一个新的差异表达基因表达芯片筛选。C10 orf 10在乳腺癌组织中的表达明显低于癌旁组织（81/95，P = 0.0063）。 Kaplan-Meier分析显示，C10 orf 10低表达患者在mRNA水平（n = 1115，P = 0.0013）和蛋白水平（n = 100，P = 0.003）的预后均较差。 单因素和多因素分析显示C10 orf 10表达是影响乳腺癌患者总生存率的独立预后因素。进一步分析发现，C10 orf 10的低表达对管腔A型、管腔B型、Her 2+型、组织学分级2级、淋巴结阴性、ER阳性患者的预后不利。我们的数据提供了第一个证据表明，C10 orf 10表达经常在乳腺癌组织中降低，C10 orf 10的低表达可能是乳腺癌患者生存时间较差的一个重要预后因素。
Breast cancer is a common malignant tumor, which severely threatens the health of women with an increasing incidence in many countries. Here, we identified C10orf10 as a novel differentially expression gene using expression microarray screening. The expression analysis indicated that C10orf10 was frequently decreased in human breast cancers compared to noncancerous breast tissues (81/95, P = 0.0063). Kaplan-Meier analysis indicated that patients with low C10orf10 expression showed a poorer prognosis both in mRNA (n = 1115, P = 0.0013) and protein (n = 100, P = 0.003) levels. Univariate and multivariate analysis showed that the C10orf10 expression was an independent prognostic factor for overall survival of breast cancer patients. Further analysis revealed that low expression of C10orf10 was an unfavorable factor for the prognosis of the patients who were luminal A, luminal B, Her2+ subtypes, at histological grade 2, lymph node negative and ER positive. Our data provided the first evidence that C10orf10 expression was frequently decreased in breast cancer tissues, and low expression of C10orf10 may be an important prognostic factor for poorer survival time of breast cancer patients.
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5.7
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通讯作者：
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