Uterine contractile responses to endothelin-1 and endothelin receptors are elevated during labor.
Uterine contractile responses to endothelin-1 and endothelin receptors are elevated during labor.
复制标题
分娩期间子宫对内皮素-1 和内皮素受体的收缩反应增强。
作者：
C. Yallampalli;R. Garfield
The purpose of this study was to determine whether the contractile responsiveness of the rat uterus to endothelin (ET)-1 and myometrial ET-1 receptors is elevated during labor. Uterine contractile responses to ET-1 were measured in isolated uterine strips obtained from rats on Day 18 of gestation, during spontaneous labor at term, and on Days 1 and 2 postpartum. The mean force (millinewtons) generated by cumulative addition of ET-1 (10(-10)-10(-6) M) was measured in vitro. Cumulative dose-response curves were created based upon the contractile activity vs. log doses of ET-1. The values of the estimated pD2, Emax, and slope of the dose-response curves were significantly (p < 0.05) higher in tissues taken during delivery than in tissues from animals on Day 18 of gestation or Days 1 and 2 postpartum. Myometrial ET-1 receptors were also measured during pregnancy and labor. Scatchard analysis of the ET-1 binding to myometrial membranes revealed that receptor levels were significantly (p < 0.05) elevated in delivering animals, without changes in their affinity. Our study shows that the uterus is more sensitive and responsive to the contractile effects of ET-1 during labor, at term, when the receptor density is increased. The change in ET-1 responsiveness at term may play a role in the initiation and/or progression of labor.
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DOI：
10.1016/s0021-9258(18)54460-4
发表时间：
1991-12
期刊：
The Journal of biological chemistry
影响因子：
--
作者：
M. Casey;Jesse W. Smith;K. Nagai;L. Hersh;P. Macdonald
通讯作者：
M. Casey;Jesse W. Smith;K. Nagai;L. Hersh;P. Macdonald
内皮素作用：蛋白激酶 C 抑制剂的抑制和磷酸肌醇的参与。
DOI：
10.1016/s0006-291x(89)80193-7
发表时间：
1989
影响因子：
3.1
作者：
Sugiura,M;Inagami,T;Hare,GM;Johns,JA
通讯作者：
Johns,JA
妊娠中期和足月自然分娩前和自然分娩期间人类羊水中的内皮素水平。
DOI：
10.1210/jcem.76.6.8501173
发表时间：
1993
期刊：
The Journal of clinical endocrinology and metabolism
影响因子：
--
作者：
Casey,ML;Brown,CE;Peters,M;MacDonald,PC
通讯作者：
MacDonald,PC
细胞表面内皮素受体的异质性。
DOI：
--
发表时间：
1990
期刊：
The Journal of biological chemistry
影响因子：
--
作者：
Martin,ER;Brenner,BM;Ballermann,BJ
通讯作者：
Ballermann,BJ
人无血管羊膜中内皮素 1 基因表达及内皮素 mRNA 和蛋白质生物合成的调节。
DOI：
--
发表时间：
1991
期刊：
The Journal of biological chemistry
影响因子：
--
作者：
Casey,ML;Word,RA;MacDonald,PC
通讯作者：
MacDonald,PC