Yes-associated protein is an independent prognostic marker in hepatocellular carcinoma.
Yes-associated protein is an independent prognostic marker in hepatocellular carcinoma.
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DOI：
10.1002/cncr.24495
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发表时间：
2009-10-01
期刊：
影响因子：
6.2
通讯作者：
Luk, John M.
中科院分区：
文献类型：
--
作者：
Xu, Michelle Z.;Yao, Tzy-Jyun;Lee, Nikki P. Y.;Ng, Irene O. L.;Chan, Yuk-Tat;Zender, Lars;Lowe, Scott W.;Poon, Ronnie T. P.;Luk, John M.
是相关蛋白（雅普）是Hippo信号通路的下游靶点，最近在小鼠肝细胞癌（HCC）模型中发现其与肝癌发生有关。本研究的目的是探讨雅普在HCC中的临床意义及其在预测生存和肿瘤复发方面的预后价值。作者收集了177对HCC患者的肿瘤和邻近非肿瘤组织，并提供了明确的临床病理和随访数据。雅普表达通过免疫组化、Western印迹分析和定量聚合酶链反应测定。采用Pearson卡方检验分析雅普与各临床病理特征的关系，Kaplan-Meier曲线和log-rank检验分析HCC特异性无病生存期和总生存期。还对HCC中的雅普进行了多变量考克斯回归分析。雅普在大多数HCC病例中表达（约62%），主要积聚在肿瘤细胞核中。HCC中雅普的过表达与肿瘤分化较差（Edmonson分级; P = 0.021）和高血清甲胎蛋白（AFP）水平显著相关（P <0.001）。Kaplan-Meier和考克斯回归数据表明，雅普是HCC特异性无病生存期（风险比[HR]，1.653; 95%置信区间[95% CI]，1.081-2.528 [P = .02]）和总生存期（HR，2.148; 95% CI，1.255-3.677 [P = .005]）的独立预测因子。雅普是HCC患者总生存期和无病生存期的独立预后指标，与肿瘤分化程度和血清AFP水平有临床病理相关性。它是这种侵袭性恶性肿瘤的潜在治疗靶点。
Yes-associated protein (YAP), a downstream target of the Hippo signaling pathway, was recently linked to hepatocarcinogenesis in a mouse hepatocellular carcinoma (HCC) model. The objective of the current study was to investigate the clinical significance of YAP in HCC and its prognostic values in predicting survival and tumor recurrence. The authors collected 177 pairs of tumor and adjacent nontumor tissue from HCC patients with definitive clinicopathologic and follow-up data. YAP expression was determined by immunohistochemistry, Western blot analysis, and quantitative polymerase chain reaction. Association of YAP with each clinicopathologic feature was analyzed by Pearson chi-square test, and HCC-specific disease-free survival and overall survival by Kaplan-Meier curves and log-rank test. Multivariate Cox regression analyses of YAP in HCC were also performed. YAP was expressed in the majority of HCC cases (approximately 62%) and mainly accumulated in the tumor nucleus. Overexpression of YAP in HCC was significantly associated with poorer tumor differentiation (Edmonson grade; P = .021) and high serum α-fetoprotein (AFP) level (P < .001). Kaplan-Meier and Cox regression data indicated that YAP was an independent predictor for HCC-specific disease-free survival (hazards ratio [HR], 1.653; 95% confidence interval [95% CI], 1.081-2.528 [P = .02]) and overall survival (HR, 2.148; 95% CI, 1.255-3.677 [P = .005]). YAP is an independent prognostic marker for overall survival and disease-free survival times of HCC patients and clinicopathologically associated with tumor differentiation and serum AFP level. It is a potential therapeutic target for this aggressive malignancy.
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影响因子：
1.9
作者：
Poon, Ronnie Tung-Ping;Fan, Sheung-Tat
通讯作者：
Fan, Sheung-Tat
影响因子：
45.3
作者：
Poon, RTP;Fan, ST;Wong, J
通讯作者：
Wong, J
影响因子：
64.5
作者：
Dong, Jixin;Feldmann, Georg;Pan, Duojia
通讯作者：
Pan, Duojia
影响因子：
3.4
作者：
Luk, JM;Lam, CT;Fan, ST
通讯作者：
Fan, ST
影响因子：
2.9
作者：
El-Serag, HB
通讯作者：
El-Serag, HB