Enhanced mindfulness-based stress reduction in episodic migraine-effects on sleep quality, anxiety, stress, and depression: a secondary analysis of a randomized clinical trial.
Enhanced mindfulness-based stress reduction in episodic migraine-effects on sleep quality, anxiety, stress, and depression: a secondary analysis of a randomized clinical trial.
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增强正念减压对间歇性偏头痛睡眠质量、焦虑、压力和抑郁的影响：一项随机临床试验的二次分析。
DOI：
10.1097/j.pain.0000000000002372
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发表时间：
2022-03-01
期刊：
影响因子：
7.4
通讯作者：
Seminowicz DA
中科院分区：
文献类型：
--
作者：
Burrowes SAB;Goloubeva O;Stafford K;McArdle PF;Goyal M;Peterlin BL;Haythornthwaite JA;Seminowicz DA
偏头痛患者的高发病率与这种疾病的特征反复头痛发作、睡眠不佳和高患病率的心理社会障碍有关。目前的药物治疗没有解决偏头痛的这些方面，但非药物治疗，如基于正念的压力减轻(MBSR)已被证明可以改善疼痛和心理健康。在这项二次分析中，我们检查了正念冥想临床试验中MRI结果对睡眠质量和心理社会结果随时间的变化，并评估了这些因素如何调节治疗反应(干预后头痛频率减少50%)。我们还检查了基线值和治疗反应之间的关系。这项试验(先前报道的主要结果)包括98名发作性偏头痛患者，他们被随机分为增强型MBSR(MBSR+)或头痛压力管理(SMH)组。他们在基线(干预前)、干预中期(基线后10周)和干预后(基线后20周)完成了心理社会问卷和头痛日记。从基线到干预后，两组的睡眠质量都有了显著的改善(p=0.0025)。在焦虑、抑郁和压力方面，与基线相比或在组间没有显著变化。基线评分和治疗反应之间也没有明显的关联。中介分析显示，6%的睡眠对睡眠有显著的间接影响：换句话说，睡眠的微小改善可能有助于MBSR+的疗效。NCT02133209
Migraine patients suffer from high morbidity related to the repeated headache attacks characteristic of the disorder, poor sleep and a high prevalence of co-morbid psychosocial disorders. Current pharmacological therapies do not address these aspects of migraine, but non-pharmacological treatments such as Mindfulness Based Stress Reduction (MBSR) have been shown to improve both pain and psychological well-being. In this secondary analysis, we examined the change over time in sleep quality and psychosocial outcomes from the MRI Outcomes for Mindfulness Meditation Clinical Trial and assessed how these mediated treatment response (50% reduction in headache frequency post-intervention). We also examined the relationship between baseline values and treatment response. The trial (primary outcomes previously reported) included 98 episodic migraine patients randomized to either enhanced MBSR (MBSR+) or stress management for headache (SMH). They completed psychosocial questionnaires and headache diaries at baseline (pre-intervention), mid-intervention (10 weeks post baseline) and post-intervention (20 weeks post baseline). There was a significant improvement in sleep quality from baseline to post-intervention (p=0.0025), in both groups. There were no significant changes from baseline or between groups in anxiety, depression and stress. There was also no significant association between baseline scores and treatment response. Mediation analysis showed a significant indirect effect of 6% for sleep: in other words, small improvements in sleep may have contributed to the efficacy of MBSR+. NCT02133209
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影响因子：
5
作者：
COHEN, S;KAMARCK, T;MERMELSTEIN, R
通讯作者：
MERMELSTEIN, R
DOI：
10.1007/s12160-016-9844-2
发表时间：
2017-04
期刊：
Annals of behavioral medicine : a publication of the Society of Behavioral Medicine
影响因子：
--
作者：
Hilton L;Hempel S;Ewing BA;Apaydin E;Xenakis L;Newberry S;Colaiaco B;Maher AR;Shanman RM;Sorbero ME;Maglione MA
通讯作者：
Maglione MA
影响因子：
5
作者：
Fuller-Thomson, Esme;Jayanthikumar, Janany;Agbeyaka, Senyo K.
通讯作者：
Agbeyaka, Senyo K.
影响因子：
5
作者：
Lipton, Richard B.;Silberstein, Stephen D.
通讯作者：
Silberstein, Stephen D.
影响因子：
2.7
作者：
Pancheri, Corinna;Maraone, Annalisa;Tarsitani, Lorenzo
通讯作者：
Tarsitani, Lorenzo