Medial Parabrachial Nucleus Is Essential in Controlling Wakefulness in Rats.
Medial Parabrachial Nucleus Is Essential in Controlling Wakefulness in Rats.
复制标题
内侧臂旁核对于控制大鼠的觉醒至关重要
DOI：
10.3389/fnins.2021.645877
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发表时间：
2021
影响因子：
4.3
通讯作者：
Huang ZL
中科院分区：
文献类型：
--
作者：
Xu Q;Wang DR;Dong H;Chen L;Lu J;Lazarus M;Cherasse Y;Chen GH;Qu WM;Huang ZL
脑干臂旁核（PB）的激活可诱导大鼠觉醒，提示PB是控制觉醒的重要核团。然而，PB在调节睡眠-觉醒周期中的亚区域仍不清楚。在这里，我们采用化学遗传学和光遗传学策略，发现PB内侧部分（MPB）的激活，而不是外侧部分，诱导连续觉醒10小时，无论是睡眠量还是功率谱都没有睡眠反弹。睡眠大鼠MPB能神经元的光发生激活由基底前脑（BF）和外侧下丘脑（LH）介导，而不是腹内侧丘脑。最重要的是，PB神经元的化学发生抑制减少了10小时的觉醒。总之，这些结果表明，多巴胺能MPB神经元在控制觉醒是必不可少的，MPB-BF和MPB-LH途径是主要的神经回路。
Activation of the parabrachial nucleus (PB) in the brainstem induced wakefulness in rats, suggesting which is an important nucleus that controls arousal. However, the sub-regions of PB in regulating sleep-wake cycle is still unclear. Here, we employ chemogenetics and optogenetics strategies and find that activation of the medial part of PB (MPB), but not the lateral part, induces continuous wakefulness for 10 h without sleep rebound in neither sleep amount nor the power spectra. Optogenetic activation of glutamatergic MPB neurons in sleeping rats immediately wake rats mediated by the basal forebrain (BF) and lateral hypothalamus (LH), but not the ventral medial thalamus. Most importantly, chemogenetic inhibition of PB neurons decreases wakefulness for 10 h. Conclusively, these findings indicate that the glutamatergic MPB neurons are essential in controlling wakefulness, and that MPB-BF and MPB-LH pathways are the major neuronal circuits.
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影响因子：
5.3
作者：
Bourgeais, L;Monconduit, L;Bernard, JF
通讯作者：
Bernard, JF
影响因子：
16.6
作者：
Honjoh S;Sasai S;Schiereck SS;Nagai H;Tononi G;Cirelli C
通讯作者：
Cirelli C
影响因子：
16.6
作者：
Anaclet C;Pedersen NP;Ferrari LL;Venner A;Bass CE;Arrigoni E;Fuller PM
通讯作者：
Fuller PM
影响因子：
2.5
作者：
HERKENHAM, M
通讯作者：
HERKENHAM, M
影响因子：
64.5
作者：
Chemelli, RM;Willie, JT;Yanagisawa, M
通讯作者：
Yanagisawa, M