Therapeutic Potential of Ginsenosides as an Adjuvant Treatment for Diabetes.
Therapeutic Potential of Ginsenosides as an Adjuvant Treatment for Diabetes.
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DOI：
10.3389/fphar.2018.00423
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发表时间：
2018
影响因子：
5.6
通讯作者：
Wei J
中科院分区：
文献类型：
--
作者：
Bai L;Gao J;Wei F;Zhao J;Wang D;Wei J
人参是最古老的传统中药材之一，在中国和亚洲被广泛使用已有数千年的历史。人参是从人参科植物人参Panax ginseng C. A. Meyer，在中国已被用作治疗糖尿病的辅助药物。由于甘草生产的技术复杂性，通常提取总甘草苷。越来越多的证据表明，黄芪皂苷具有抗糖尿病作用。体内和体外试验表明，人参皂苷Rg 1、Rg 3、Rg 5、Rb 1、Rb 2、Rb 3、化合物K、Rk 1、Re、人参总皂苷、丙二酰人参皂苷、Rd、Rh 2、F2、原人参二醇（PPD）和原人参三醇（PPT）型皂苷具有治疗糖尿病及其并发症的潜力，包括1型糖尿病、2型糖尿病、糖尿病肾病、糖尿病认知功能障碍，2型糖尿病伴脂肪肝、糖尿病脑梗死、糖尿病心肌病和糖尿病勃起功能障碍。许多作用归因于皂苷，包括减少新生血管生成、改善胰岛素抵抗、葡萄糖转运、促胰岛素作用、胰岛细胞保护、肝保护活性、抗炎作用、心肌保护、脂质调节、改善葡萄糖耐量、抗氧化、改善勃起功能障碍、调节肠道植物群代谢、神经保护、抗血管病、抗神经毒性作用、免疫抑制、肾保护作用。这些作用的分子靶点主要包括GLUTs、SGLT 1、GLP-1、FoxO 1、TNF-α、IL-6、caspase-3、bcl-2、MDA、SOD、STAT 5-PPAR γ通路、PI 3 K/Akt通路、AMPK-JNK通路、NF-κB通路和内质网应激。Rg 1、Rg 3、Rb 1和化合物K是最有前景的糖尿病辅助治疗药物。本文重点介绍了黄芪皂苷抗糖尿病作用的药理学机制。
Ginseng, one of the oldest traditional Chinese medicinal herbs, has been used widely in China and Asia for thousands of years. Ginsenosides extracted from ginseng, which is derived from the roots and rhizomes of Panax ginseng C. A. Meyer, have been used in China as an adjuvant in the treatment of diabetes mellitus. Owing to the technical complexity of ginsenoside production, the total ginsenosides are generally extracted. Accumulating evidence has shown that ginsenosides exert antidiabetic effects. In vivo and in vitro tests revealed the potential of ginsenoside Rg1, Rg3, Rg5, Rb1, Rb2, Rb3, compound K, Rk1, Re, ginseng total saponins, malonyl ginsenosides, Rd, Rh2, F2, protopanaxadiol (PPD) and protopanaxatriol (PPT)-type saponins to treat diabetes and its complications, including type 1 diabetes mellitus, type 2 diabetes mellitus, diabetic nephropathy, diabetic cognitive dysfunction, type 2 diabetes mellitus with fatty liver disease, diabetic cerebral infarction, diabetic cardiomyopathy, and diabetic erectile dysfunction. Many effects are attributed to ginsenosides, including gluconeogenesis reduction, improvement of insulin resistance, glucose transport, insulinotropic action, islet cell protection, hepatoprotective activity, anti-inflammatory effect, myocardial protection, lipid regulation, improvement of glucose tolerance, antioxidation, improvement of erectile dysfunction, regulation of gut flora metabolism, neuroprotection, anti-angiopathy, anti-neurotoxic effects, immunosuppression, and renoprotection effect. The molecular targets of these effects mainly contains GLUTs, SGLT1, GLP-1, FoxO1, TNF-α, IL-6, caspase-3, bcl-2, MDA, SOD, STAT5-PPAR gamma pathway, PI3K/Akt pathway, AMPK-JNK pathway, NF-κB pathway, and endoplasmic reticulum stress. Rg1, Rg3, Rb1, and compound K demonstrated the most promising therapeutic prospects as potential adjuvant medicines for the treatment of diabetes. This paper highlights the underlying pharmacological mechanisms of the anti-diabetic effects of ginsenosides.
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原人参二醇和原人参三醇型皂苷可改善高脂饮食/链脲佐菌素诱导的 2 型糖尿病小鼠的葡萄糖和脂质代谢
影响因子：
5.6
作者：
Deng J;Liu Y;Duan Z;Zhu C;Hui J;Mi Y;Ma P;Ma X;Fan D;Yang H
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影响因子：
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作者：
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Fargion, Silvia
DOI：
10.1124/jpet.113.210716
发表时间：
2014-04-01
影响因子：
3.5
作者：
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通讯作者：
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