Protopanaxadiol and Protopanaxatriol-Type Saponins Ameliorate Glucose and Lipid Metabolism in Type 2 Diabetes Mellitus in High-Fat Diet/Streptozocin-Induced Mice.
Protopanaxadiol and Protopanaxatriol-Type Saponins Ameliorate Glucose and Lipid Metabolism in Type 2 Diabetes Mellitus in High-Fat Diet/Streptozocin-Induced Mice.
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原人参二醇和原人参三醇型皂苷可改善高脂饮食/链脲佐菌素诱导的 2 型糖尿病小鼠的葡萄糖和脂质代谢
DOI：
10.3389/fphar.2017.00506
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发表时间：
2017
影响因子：
5.6
通讯作者：
Yang H
中科院分区：
文献类型：
--
作者：
Deng J;Liu Y;Duan Z;Zhu C;Hui J;Mi Y;Ma P;Ma X;Fan D;Yang H
人参皂苷是人参的主要活性成分，具有保肝、抑制肿瘤、抗糖尿病等多种药理作用。在本研究中，探索并比较了原人参二醇 (PPD) 和原人参三醇 (PPT) 型皂苷在高脂饮食/链佐星诱导的 2 型糖尿病 (T2DM) 小鼠中的抗糖尿病作用。我们的结果表明，低或高剂量（50 mg/kg 体重或 150 mg/kg 体重）PPD 和 PPT 显着降低 T2DM 小鼠的空腹血糖，改善糖耐量和胰岛素抵抗。 PPD 和 PPT 还可以调节 T2DM 小鼠的血清脂质相关标志物，例如降低总胆固醇 (TC)、甘油三酯 (TG) 和低密度脂蛋白胆固醇。此外，PPD和PPT通过抑制血清中肿瘤坏死因子-α和白细胞介素-6等促炎细胞因子的分泌和肝脏水平中的基因表达来显着改善炎症反应，并通过增加T2DM小鼠血清中的超氧化物歧化酶和降低丙二醛水平来提高抗氧化能力。此外，PPD和PPT的抗糖尿病作用似乎部分是通过抑制肝代谢基因表达（例如过氧化物酶体增殖物激活受体γ共激活剂1-α、磷酸烯醇丙酮酸羧激酶和葡萄糖-6-磷酸酶）以及促进脂质代谢基因表达（例如 T2DM小鼠肝组织中的微粒体TG转移蛋白。总而言之，我们的结果表明，PPD 和 PPT 可能作为天然抗糖尿病化合物，在未来用于预防和治疗 T2DM 及其并发症。
Ginsenoside is a major active component of ginseng, which exhibits various pharmacological properties such as hepatoprotection, tumor suppression and diabetes resistance. In this study, the anti-diabetic effects of protopanaxadiol (PPD) and protopanaxatriol (PPT)-type saponins were explored and compared in high-fat diet/streptozocin-induced type 2 diabetes mellitus (T2DM) mice. Our results showed that low or high dose (50 mg/kg bodyweight or 150 mg/kg bodyweight) PPD and PPT significantly reduced fasting blood glucose, improved glucose tolerance and insulin resistance in T2DM mice. PPD and PPT also regulated serum lipid-related markers such as reduced total cholesterol (TC), triglyceride (TG), and low-density lipoprotein cholesterol in T2DM mice. In addition, PPD and PPT dramatically ameliorated the inflammatory responses by suppressing the secretion of pro-inflammatory cytokines like tumor necrosis factor-alpha and interleukin-6 in serum level and gene expression in liver level, and improved the antioxidant capacity by increasing the superoxide dismutase and decreasing malondialdehyde levels in the serum of T2DM mice. Moreover, the anti-diabetic effect of PPD and PPT appeared to be partially mediated by the suppression of hepatic metabolism genes expression such as peroxisome proliferator-activated receptor gamma coactivator 1-alpha, phosphoenolpyruvate carboxykinase, and glucose-6-phosphatase, as well as facilitating lipid metabolism genes expression such as microsomal TG transfer protein in the liver tissues of T2DM mice. Taken together, our results indicated that PPD and PPT might potentially act as natural anti-diabetic compounds to be used for preventing and treating the T2DM and its complications in the future.
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影响因子：
5.8
作者：
Lee, Young-Sil;Cha, Byung-Yoon;Woo, Je-Tae
通讯作者：
Woo, Je-Tae
影响因子：
5
作者：
Cho, William C. S.;Chung, Wai-Shing;Yue, Kevin K. M.
通讯作者：
Yue, Kevin K. M.
影响因子：
--
作者：
KLEIN, R;KLEIN, BEK;CRUICKSHANKS, KJ
通讯作者：
CRUICKSHANKS, KJ
DOI：
10.1111/j.1440-1681.2006.04319.x
发表时间：
2006-01-01
影响因子：
2.9
作者：
Lee, WK;Kao, ST;Cheng, JT
通讯作者：
Cheng, JT
20(S)-人参皂苷 Rg3 对链脲佐菌素诱导的实验性 2 型糖尿病大鼠的影响：通过快速分辨率液相色谱/质谱法进行的尿代谢组学研究。
影响因子：
2
作者：
Niu, Jun;Pi, Zi-Feng;Liu, Shu-Ying
通讯作者：
Liu, Shu-Ying