Diversity-oriented synthesis based on the DPPP-catalyzed mixed double-Michael reactions of electron-deficient acetylenes and β-amino alcohols.
Diversity-oriented synthesis based on the DPPP-catalyzed mixed double-Michael reactions of electron-deficient acetylenes and β-amino alcohols.
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DOI：
10.3390/molecules16053802
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发表时间：
2011-05-05
期刊：
影响因子：
--
通讯作者：
Kwon O
中科院分区：
文献类型：
--
作者：
Fan YC;Kwon O
In this study, we prepared oxizolidines through 1,3-bis(diphenylphosphino)-propane (DPPP)–catalyzed mixed double-Michael reactions of β-amino alcohols with electron-deficient acetylenes. These reactions are very suitable for the diversity-oriented parallel syntheses of oxizolidines because: (i) they are performed under mild metal-free conditions and (ii) the products are isolated without complicated work-up. To demonstrate the applicability of mixed double-Michael reactions for the preparation of five-membered-ring heterocycles, we prepared 60 distinct oxazolidines from five β-amino alcohols and 12 electron-deficient acetylenes. We synthesized 36 of these 60 oxazolidines in enantiomerically pure form from proteinogenic amino acid–derived β-amino alcohols.
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影响因子：
3.6
作者：
Maeda, Y;Kakiuchi, N;Uemura, S
通讯作者：
Uemura, S
影响因子：
3.2
作者：
Gaunt, MJ;Sneddon, HF;Ley, SV
通讯作者：
Ley, SV
DOI：
10.1073/pnas.1015254108
发表时间：
2011-04-26
影响因子：
11.1
作者：
Cruz, Daniel;Wang, Zhiming;Kwon, Ohyun
通讯作者：
Kwon, Ohyun
影响因子：
3.6
作者：
Grossman, RB;Comesse, S;Delong, MN
通讯作者：
Delong, MN
影响因子：
2.1
作者：
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通讯作者：
Kwon, Ohyun