KRAB-containing zinc-finger repressor proteins.
KRAB-containing zinc-finger repressor proteins.
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DOI：
10.1186/gb-2003-4-10-231
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发表时间：
2003
期刊：
影响因子：
12.3
通讯作者：
Urrutia R
中科院分区：
文献类型：
--
作者：
Urrutia R
锌指转录因子的最大家族包括那些含有Krüppel相关框（或KRAB结构域）的转录因子。KRAB结构域作为转录阻遏物结构域，C2H2锌指基序结合DNA。该家族的成员参与核仁的维持、细胞分化、细胞增殖、细胞凋亡和肿瘤转化。锌指转录因子的最大家族包括那些含有Krüppel相关框（或KRAB结构域）的转录因子，它们仅存在于四足脊椎动物中。许多编码含KRAB蛋白的基因在人类基因组中排列成簇，其中一个簇靠近染色体9ql3，而其他簇位于其他染色体的着丝粒和端粒区域，但其他基因单独存在于整个基因组中。KRAB结构域位于蛋白质的氨基末端区域，通过与辅阻遏蛋白结合而表现为转录阻遏结构域，而C2H2锌指基序结合DNA。目前提出的KRAB蛋白家族成员的功能包括RNA聚合酶I、II和III启动子的转录抑制以及RNA的结合和剪接。该家族的成员参与核仁的维持、细胞分化、细胞增殖、细胞凋亡和肿瘤转化。
The largest family of zinc-finger transcription factors comprises those containing the Krüppel-associated box (or KRAB domain). The KRAB domain behaves as a transcriptional repressor domain and the C2H2 zinc-finger motifs bind DNA. Members of the family are involved in maintenance of the nucleolus, cell differentiation, cell proliferation, apoptosis, and neoplastic transformation. The largest family of zinc-finger transcription factors comprises those containing the Krüppel-associated box (or KRAB domain), which are present only in tetrapod vertebrates. Many genes encoding KRAB-containing proteins are arranged in clusters in the human genome, with one cluster close to chromosome 9ql3 and others in centromeric and telomeric regions of other chromosomes, but other genes occur individually throughout the genome. The KRAB domain, which is found in the amino-terminal region of the proteins, behaves as a transcriptional repressor domain by binding to corepressor proteins, whereas the C2H2 zinc-finger motifs bind DNA. The functions currently proposed for members of the KRAB-containing protein family include transcriptional repression of RNA polymerase I, II, and III promoters and binding and splicing of RNA. Members of the family are involved in maintenance of the nucleolus, cell differentiation, cell proliferation, apoptosis, and neoplastic transformation.
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