Comparison of the FreeStyle Libre Pro Flash Continuous Glucose Monitoring (CGM) System and Point-of-Care Capillary Glucose Testing in Hospitalized Patients With Type 2 Diabetes Treated With Basal-Bolus Insulin Regimen.
Comparison of the FreeStyle Libre Pro Flash Continuous Glucose Monitoring (CGM) System and Point-of-Care Capillary Glucose Testing in Hospitalized Patients With Type 2 Diabetes Treated With Basal-Bolus Insulin Regimen.
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DOI：
10.2337/dc19-2073
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发表时间：
2020-11
期刊：
影响因子：
16.2
通讯作者：
Umpierrez GE
中科院分区：
文献类型：
--
作者：
Galindo RJ;Migdal AL;Davis GM;Urrutia MA;Albury B;Zambrano C;Vellanki P;Pasquel FJ;Fayfman M;Peng L;Umpierrez GE
我们比较了 FreeStyle Libre Pro 连续血糖监测 (CGM) 和护理点毛细血管血糖测试 (POC) 在接受胰岛素治疗的 2 型糖尿病 (T2D) 住院患者中的性能。这是一项针对入住普通内科和外科病房的成年 T2D 患者的前瞻性研究。患者在饭前和睡前接受 POC 监测，并在住院期间接受 CGM 监测。研究终点包括 POC 和 CGM 之间在平均每日血糖 (BG)、低血糖 <70 和 <54 mg/dL 以及夜间低血糖方面的差异。我们还计算了匹配葡萄糖对之间的平均绝对相对差 (MARD)、±15%/15 mg/dL、±20%/20 mg/dL 和 ±30%/30 mg/dL 以及误差网格分析。 POC 的平均每日血糖显着升高（188.9 ± 37.3 vs. 176.1 ± 46.9 mg/dL），估计平均差异为 12.8 mg/dL（95% CI 8.3–17.2 mg/dL），并且血糖读数 <70 mg/dL（14% vs. 56%）和 <54 mg/dL（4.1% vs. 54%）的患者比例。 POC BG 检测到的（36%）显着低于 CGM（均 P < 0.001）。夜间和长期 CGM 低血糖 <54 mg/dL 的比例分别为 26% 和 12%。总体 MARD 为 14.8%，对于葡萄糖值在 70 至 250 mg/dL 之间的范围为 11.4% 至 16.7%，对于 51–69 mg/dL 的范围更高 (MARD 28.0%)。葡萄糖读数在±15%/15 mg/dL、±20%/20 mg/dL和±30%/30 mg/dL内的百分比分别为62%、76%和91%。误差网格分析显示，98.8% 的葡萄糖对位于 A 区和 B 区。与 POC 相比，FreeStyle Libre CGM 显示出较低的平均每日血糖和较高的低血糖事件检出率，特别是住院 T2D 患者的夜间和长时间低血糖。 CGM 在低血糖范围内的准确性较低。
We compared the performance of the FreeStyle Libre Pro continuous glucose monitoring (CGM) and point-of-care capillary glucose testing (POC) among insulin-treated hospitalized patients with type 2 diabetes (T2D). This was a prospective study in adult patients with T2D admitted to general medicine and surgery wards. Patients were monitored with POC before meals and bedtime and with CGM during the hospital stay. Study end points included differences between POC and CGM in mean daily blood glucose (BG), hypoglycemia <70 and <54 mg/dL, and nocturnal hypoglycemia. We also calculated the mean absolute relative difference (MARD), ±15%/15 mg/dL, ±20%/20 mg/dL, and ±30%/30 mg/dL and error grid analysis between matched glucose pairs. Mean daily glucose was significantly higher by POC (188.9 ± 37.3 vs. 176.1 ± 46.9 mg/dL) with an estimated mean difference of 12.8 mg/dL (95% CI 8.3–17.2 mg/dL), and proportions of patients with glucose readings <70 mg/dL (14% vs. 56%) and <54 mg/dL (4.1% vs. 36%) detected by POC BG were significantly lower compared with CGM (all P < 0.001). Nocturnal and prolonged CGM hypoglycemia <54 mg/dL were 26% and 12%, respectively. The overall MARD was 14.8%, ranging between 11.4% and 16.7% for glucose values between 70 and 250 mg/dL and higher for 51–69 mg/dL (MARD 28.0%). The percentages of glucose readings within ±15%/15 mg/dL, ±20%/20 mg/dL, and ±30%/30 mg/dL were 62%, 76%, and 91%, respectively. Error grid analysis showed 98.8% of glucose pairs within zones A and B. Compared with POC, FreeStyle Libre CGM showed lower mean daily glucose and higher detection of hypoglycemic events, particularly nocturnal and prolonged hypoglycemia in hospitalized patients with T2D. CGM’s accuracy was lower in the hypoglycemic range.
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影响因子：
16.2
作者：
Danne T;Nimri R;Battelino T;Bergenstal RM;Close KL;DeVries JH;Garg S;Heinemann L;Hirsch I;Amiel SA;Beck R;Bosi E;Buckingham B;Cobelli C;Dassau E;Doyle FJ 3rd;Heller S;Hovorka R;Jia W;Jones T;Kordonouri O;Kovatchev B;Kowalski A;Laffel L;Maahs D;Murphy HR;Nørgaard K;Parkin CG;Renard E;Saboo B;Scharf M;Tamborlane WV;Weinzimer SA;Phillip M
通讯作者：
Phillip M
影响因子：
5.4
作者：
Bailey T;Bode BW;Christiansen MP;Klaff LJ;Alva S
通讯作者：
Alva S
影响因子：
4.1
作者：
Cardona, Saumeth;Gomez, Patricia C.;Umpierrez, Guillermo E.
通讯作者：
Umpierrez, Guillermo E.
影响因子：
5.8
作者：
Aberer, Felix;Hajnsek, Martin;Mader, Julia K.
通讯作者：
Mader, Julia K.
影响因子：
5.8
作者：
Burt, Morton G.;Roberts, Gregory W.;Stranks, Stephen N.
通讯作者：
Stranks, Stephen N.