Risks of Depression and Suicide After Diagnosis With Heart Failure: A National Cohort Study.
Risks of Depression and Suicide After Diagnosis With Heart Failure: A National Cohort Study.
复制标题
心衰诊断后抑郁和自杀的风险：一项国家队列研究。
DOI：
10.1016/j.jchf.2022.07.007
复制
发表时间：
2022-11
影响因子：
13
通讯作者：
Sundquist, Kristina
中科院分区：
文献类型：
--
作者：
Crump, Casey;Sundquist, Jan;Kendler, Kenneth S.;Sieh, Weiva;Edwards, Alexis C.;Sundquist, Kristina
心力衰竭（HF）与心理社会困扰有关，但其他长期精神健康后遗症尚不清楚。在一个大型人群队列中确定心力衰竭诊断后重性抑郁和自杀的风险、易感时间段和性别特异性差异。对2002 - 2017年期间在瑞典诊断为18 - 75岁HF的所有154，572人以及1，545，720名年龄和性别匹配的基于人群的对照进行了一项国家队列研究，随访了2018年全国住院，门诊和死亡记录中确定的重度抑郁症和自杀。Poisson回归用于计算发病率比（IRR），同时调整社会人口因素和合并症。在男性和女性中，HF与重度抑郁症和自杀死亡的风险增加相关，在HF诊断后的前3个月内风险最高，然后在≥ 12个月时降至中度风险。HF诊断后3个月内，男性新发重性抑郁症的校正IRR为3.34（95%CI，3.04 - 3.68），女性为2.78（2.51 - 3.09），男性自杀死亡的校正IRR为4.47（2.62 - 7.62），女性为2.82（1.11 - 7.12）。无论HF诊断时的年龄如何，这些风险均升高。HF与女性抑郁症病例显著相关（P <0.001）。在这个大型的国家队列中，HF与男性和女性抑郁和自杀的风险大幅增加相关，最高风险发生在HF诊断后3个月内。患有HF的男性和女性需要及时发现和治疗抑郁症和自杀倾向。心力衰竭（HF）与可能对临床结局产生不利影响的心理社会困扰有关，但重度抑郁症和自杀的风险、易感时间段和性别特异性差异尚不清楚。在一项由154，572名新诊断为HF的成年人和1，545，720名年龄和性别匹配的对照者组成的全国队列中，HF与男性和女性在随后3个月内的重度抑郁症和自杀死亡的风险相关2至4倍。无论HF诊断时的年龄如何，这些风险均升高。新诊断为HF的男性和女性需要及时发现和治疗抑郁和自杀倾向。
Heart failure (HF) has been associated with psychosocial distress, but other long-term mental health sequelae are unclear. To determine risks of major depression and suicide, susceptible time periods, and sex-specific differences after HF diagnosis in a large population-based cohort. A national cohort study was conducted of all 154,572 persons diagnosed with HF at ages 18–75 years during 2002–2017 in Sweden, and 1,545,720 age- and sex-matched population-based controls, followed up for major depression and suicide ascertained from nationwide inpatient, outpatient, and death records through 2018. Poisson regression was used to compute incidence rate ratios (IRRs) while adjusting for sociodemographic factors and comorbidities. HF was associated with increased risks of major depression and death by suicide in both men and women, with highest risks in the first 3 months, then declining to modest risks at ≥12 months after HF diagnosis. Within 3 months after HF diagnosis, adjusted IRRs for new-onset major depression were 3.34 (95% CI, 3.04–3.68) in men and 2.78 (2.51–3.09) in women, and for suicide death were 4.47 (2.62–7.62) in men and 2.82 (1.11–7.12) in women. These risks were elevated regardless of age at HF diagnosis. HF was associated with significantly more depression cases in women (P<0.001). In this large national cohort, HF was associated with substantially increased risks of depression and suicide in men and women, with highest risks occurring within 3 months after HF diagnosis. Men and women with HF need timely detection and treatment of depression and suicidality. Heart failure (HF) has been associated with psychosocial distress that may adversely affect clinical outcomes, but risks of major depression and suicide, susceptible time periods, and sex-specific differences are unclear. In a national cohort of 154,572 adults newly diagnosed with HF and 1,545,720 age- and sex-matched controls, HF was associated with 2- to 4-fold risks of major depression and death by suicide in the subsequent 3 months among men and women. These risks were elevated regardless of age at HF diagnosis. Men and women newly diagnosed with HF need timely detection and treatment of depression and suicidality.
登录
查看更多内容
影响因子：
18.2
作者：
Groenewegen A;Rutten FH;Mosterd A;Hoes AW
通讯作者：
Hoes AW
影响因子：
6
作者：
Chouairi, Fouad;Fuery, Michael A.;Ahmad, Tariq
通讯作者：
Ahmad, Tariq
影响因子：
6
作者：
Mueller-Tasch, Thomas;Peters-Klimm, Frank;Herzog, Wolfgang
通讯作者：
Herzog, Wolfgang
影响因子：
5.4
作者：
Van de Velde, Sarah;Bracke, Piet;Levecque, Katia
通讯作者：
Levecque, Katia
影响因子：
6
作者：
Faller, Hermann;Stoerk, Stefan;Angermann, Christiane E.
通讯作者：
Angermann, Christiane E.