Potential Impact of Human Cytomegalovirus Infection on Immunity to Ovarian Tumours and Cancer Progression.
Potential Impact of Human Cytomegalovirus Infection on Immunity to Ovarian Tumours and Cancer Progression.
复制标题
DOI：
10.3390/biomedicines9040351
复制
发表时间：
2021-03-30
期刊：
影响因子：
4.7
通讯作者：
Plebanski M
中科院分区：
文献类型：
--
作者：
Cox M;Kartikasari AER;Gorry PR;Flanagan KL;Plebanski M
卵巢癌（OC）是影响女性的最常见和威胁生命的妇科癌症之一。几乎75%的OC病例在晚期被诊断出来，5年生存率不到30%。该病的病因尚不清楚，目前尚无筛查方法和有效的治疗策略。越来越多的证据表明，人巨细胞病毒（HCMV）感染超过50%的世界人口，可能通过其免疫调节活性在诱导癌症发生中发挥作用。在健康受试者中，原发性HCMV感染基本上无症状。然后，该病毒主要在骨髓中的造血祖细胞中建立终身慢性潜伏期，并从潜伏期定期重新激活，其特征通常是高水平的循环促炎细胞因子。目前，感染诱导的慢性炎症被认为是OC进展和转移的重要过程。与这一观察结果一致，最近很少有研究发现OC组织活检中HCMV蛋白的高表达与不良生存结局相关。因此，OC肿瘤微环境中的活动性HCMV感染可能直接导致OC进展。在这篇综述中，我们强调了HCMV感染诱导的免疫调节作用对OC的宿主免疫反应的潜在影响，可能会促进OC的进展。
Ovarian cancer (OC) is one of the most common, and life-threatening gynaecological cancer affecting females. Almost 75% of all OC cases are diagnosed at late stages, where the 5-year survival rate is less than 30%. The aetiology of the disease is still unclear, and there are currently no screening method nor effective treatment strategies for the advanced disease. A growing body of evidence shows that human cytomegalovirus (HCMV) infecting more than 50% of the world population, may play a role in inducing carcinogenesis through its immunomodulatory activities. In healthy subjects, the primary HCMV infection is essentially asymptomatic. The virus then establishes a life-long chronic latency primarily in the hematopoietic progenitor cells in the bone marrow, with periodic reactivation from latency that is often characterized by high levels of circulating pro-inflammatory cytokines. Currently, infection-induced chronic inflammation is considered as an essential process for OC progression and metastasis. In line with this observation, few recent studies have identified high expressions of HCMV proteins on OC tissue biopsies that were associated with poor survival outcomes. Active HCMV infection in the OC tumour microenvironment may thus directly contribute to OC progression. In this review, we highlight the potential impact of HCMV infection-induced immunomodulatory effects on host immune responses to OC that may promote OC progression.
登录
查看更多内容
影响因子：
--
作者：
Dong Y;Sun Q;Zhang X
通讯作者：
Zhang X
影响因子：
6.4
作者：
Di Bona, Danilo;Scafidi, Valeria;Caruso, Calogero
通讯作者：
Caruso, Calogero
DOI：
10.1016/j.bbmt.2009.03.022
发表时间：
2009-07
期刊：
Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation
影响因子：
--
作者：
Gallez-Hawkins GM;Thao L;Palmer J;Dagis A;Li X;Franck AE;Tegtmeier B;Lacey SF;Diamond DJ;Forman SJ;Zaia JA
通讯作者：
Zaia JA
影响因子：
15.1
作者：
Bennett, Jeanette M.;Glaser, Ronald;Malarkey, William B.;Beversdorf, David Q.;Peng, Juan;Kiecolt-Glaser, Janice K.
通讯作者：
Kiecolt-Glaser, Janice K.
DOI：
10.1084/jem.20090847
发表时间：
2009-12-21
期刊：
The Journal of experimental medicine
影响因子：
--
作者：
Francisco LM;Salinas VH;Brown KE;Vanguri VK;Freeman GJ;Kuchroo VK;Sharpe AH
通讯作者：
Sharpe AH