Inflammation and reactivation of latent herpesviruses in older adults.
Inflammation and reactivation of latent herpesviruses in older adults.
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DOI：
10.1016/j.bbi.2011.11.007
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发表时间：
2012-07
影响因子：
15.1
通讯作者：
Kiecolt-Glaser, Janice K.
中科院分区：
文献类型：
--
作者：
Bennett, Jeanette M.;Glaser, Ronald;Malarkey, William B.;Beversdorf, David Q.;Peng, Juan;Kiecolt-Glaser, Janice K.
关键词：
炎症随着年龄的增长而增加，并与老年人中流行的许多慢性疾病有关。潜伏性疱疹病毒和慢性细菌感染等持续性病原体可作为炎症的来源。疱疹病毒，包括eb病毒（EBV）和巨细胞病毒（CMV），在原发性感染后建立潜伏感染，并在细胞免疫系统受损时重新激活。EBV和CMV的复制可以诱导促炎细胞因子的产生，从而影响全身炎症。本研究研究了222名社区老年人（平均年龄= 64.1±14.1岁）EBV和CMV抗体滴度以及c反应蛋白（CRP）和白细胞介素-6 （IL-6）水平之间的关系。参与者根据是否EBV血清阳性和CMV血清阴性（EBV+CMV -）或EBV和CMV血清阳性（EBV+CMV+）分为两组。在EBV+CMV -的个体中，EBV抗体滴度与CRP或IL-6水平无关。然而，在EBV+CMV+的人群中，EBV抗体滴度较高的个体与CMV抗体滴度较高的个体CRP和IL-6水平升高有关；在CMV抗体滴度较低的参与者中，EBV抗体滴度与CRP或IL-6水平没有关系。这些数据表明潜伏EBV和巨细胞病毒再激活（以抗体滴度为指标）的结合可能促进CRP和IL-6的产生。因此，多种疱疹病毒的再激活可能会引发炎症，并可能导致老年人的健康状况恶化。
Inflammation increases with age and is associated with many chronic diseases that are prevalent among older adults. Persistent pathogens such as latent herpesviruses and chronic bacterial infections can act as a source of inflammation. Herpesviruses, including Epstein-Barr virus (EBV) and cytomegalovirus (CMV), establish latent infections following primary infection and reactivate when the cellular immune system is compromised. EBV and CMV replication can induce proinflammatory cytokine production and thus could influence systemic inflammation. The present study addressed relationships among EBV and CMV antibody titers, and levels of C-reactive protein (CRP) and interleukin-6 (IL-6) in a sample of 222 community dwelling older adults (meanage= 64.1 ± 14.1 years). Participants were divided into two groups based on whether they were EBV seropositive and CMV seronegative (EBV+CMV−), or EBV and CMV seropositive (EBV+CMV+). Among individuals who were EBV+CMV−, EBV antibody titers were not associated with either CRP or IL-6 levels. However, among those who were EBV+CMV+, higher EBV antibody titers were related to elevated levels of CRP and IL-6 in those individuals with higher CMV antibody titers; there was no relationship between EBV antibody titers and CRP or IL-6 levels in those participants with lower CMV antibody titers. These data suggest that the combination of latent EBV and CMV reactivation (indexed by antibody titers) may boost CRP and IL-6 production. Thus, reactivation of multiple herpesviruses may drive inflammation and could contribute to poorer health among older adults.
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影响因子：
4.7
作者：
Backhaus, J;Junghanns, K;Hohagen, F
通讯作者：
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DOI：
10.1161/01.atv.0000078603.90302.4a
发表时间：
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作者：
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