Different means, same end-heterochromatin formation by RNAi and RNAi-independent RNA processing factors in fission yeast.
Different means, same end-heterochromatin formation by RNAi and RNAi-independent RNA processing factors in fission yeast.
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DOI：
10.1016/j.gde.2011.12.004
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发表时间：
2012-04
影响因子：
4
通讯作者：
Grewal, Shiv I. S.
中科院分区：
文献类型：
--
作者：
Reyes-Turcu, Francisca E.;Grewal, Shiv I. S.
异染色质在真核生物基因组中的组装对多种染色体事件至关重要，包括基因表达的调节、重复DNA元件的沉默、染色体的适当分离和维持基因组的完整性。先前的研究表明，非编码RNA和RNAi机制促进了异染色质的组装，异染色质作为一个多用途的平台，用于靶向参与各种染色体过程的效应器。最近的工作表明，RNAi不依赖的机制，包括利用非编码和编码RNA的RNA处理活动，在异染色质的组装中起作用。这些发现已经证实，除了编码蛋白质外，mRNAs还作为信号分子发挥作用，通过靶向异染色质组装因子来改变染色质结构。
The assembly of heterochromatin in eukaryotic genomes is critical for diverse chromosomal events including regulation of gene expression, silencing of repetitive DNA elements, proper segregation of chromosomes and maintenance of genomic integrity. Previous studies have shown that non-coding RNAs and the RNAi machinery promote the assembly of heterochromatin that serves as a multipurpose platform for targeting effectors involved in various chromosomal processes. Recent work has revealed that RNAi-independent mechanisms, involving RNA processing activities that utilize both non-coding and coding RNAs, operate in the assembly of heterochromatin. These findings have established that, in addition to coding for proteins, mRNAs also function as signaling molecules that modify chromatin structure by targeting heterochromatin assembly factors.
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影响因子：
64.5
作者：
Buehler, Marc;Haas, Wilhelm;Moazed, Danesh
通讯作者：
Moazed, Danesh
影响因子：
64.5
作者：
Halic M;Moazed D
通讯作者：
Moazed D
DOI：
10.1073/pnas.0813063106
发表时间：
2009-06-02
影响因子：
11.1
作者：
Fischer, Tamas;Cui, Bowen;Grewal, Shiv I. S.
通讯作者：
Grewal, Shiv I. S.
影响因子：
21.3
作者：
Giles, Keith E.;Ghirlando, Rodolfo;Felsenfeld, Gary
通讯作者：
Felsenfeld, Gary
影响因子：
5.3
作者：
Bernard, Pascal;Drogat, Julie;Javerzat, Jean-Paul
通讯作者：
Javerzat, Jean-Paul