Quantifying antibiotic use in typhoid fever in India: a cross-sectional analysis of private sector medical audit data, 2013-2015.
Quantifying antibiotic use in typhoid fever in India: a cross-sectional analysis of private sector medical audit data, 2013-2015.
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DOI：
10.1136/bmjopen-2022-062401
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发表时间：
2022-10-17
期刊：
影响因子：
2.9
通讯作者：
Galea, Sandro
中科院分区：
文献类型：
--
作者：
Koya, Shaffi Fazaludeen;Farooqui, Habib Hasan;Mehta, Aashna;Selvaraj, Sakthivel;Galea, Sandro
估计印度伤寒的抗生素处方率。横断面研究。印度私营部门初级保健临床医生。这些数据来自一个由4600名私营部门初级保健临床医生组成的小组的处方，该小组通过多阶段分层随机抽样选出，考虑了地区、专科类型和患者流通量。该数据从IQVIA数据库中提取了2013年、2014年和2015年的6.71亿张抗生素处方。年平均抗生素处方率；按性别和年龄划分的处方率；抗生素种类分布。每年伤寒抗生素处方898万张，每10万人使用714张。以绝对数字计算，10-19岁儿童占该国总负担的18.6%，20-29岁年龄组的具体年龄比率最高，男性的平均比率（844/10万）高于女性（627/10万）。10种不同的抗生素占所有处方的72.4%。除南方地区外，头孢昔肟-氧氟沙星联合用药是所有地区治疗伤寒的首选药物。联合抗生素是成人患者的首选处方，而头孢菌素是儿童和青少年的首选处方。23.0%的病例使用喹诺酮类药物作为单药治疗。2013-2015年期间具有全国代表性的私营部门抗生素处方数据表明，印度的伤寒疾病负担高于先前估计。总处方率呈下降趋势。年轻成人患者占病例的近三分之一，10岁以下的儿童每年占100多万例。
To estimate the antibiotic prescription rates for typhoid in India. Cross-sectional study. Private sector primary care clinicians in India. The data came from prescriptions of a panel of 4600 private sector primary care clinicians selected through a multistage stratified random sampling accounting for the region, specialty type and patient turnover. The data had 671 million prescriptions for antibiotics extracted from the IQVIA database for the years 2013, 2014 and 2015. Mean annual antibiotic prescription rates; sex-specific and age-specific prescription rates; distribution of antibiotic class. There were 8.98 million antibiotic prescriptions per year for typhoid, accounting for 714 prescriptions per 100 000 population. Children 10–19 years of age represented 18.6% of the total burden in the country in absolute numbers, 20–29 year age group had the highest age-specific rate, and males had a higher average rate (844/100 000) compared with females (627/100 000). Ten different antibiotics accounted for 72.4% of all prescriptions. Cefixime–ofloxacin combination was the preferred drug of choice for typhoid across all regions except the south. Combination antibiotics are the preferred choice of prescribers for adult patients, while cephalosporins are the preferred choice for children and young age. Quinolones were prescribed as monotherapy in 23.0% of cases. Nationally representative private sector antibiotic prescription data during 2013–2015 indicate a higher disease burden of typhoid in India than previously estimated. The total prescription rate shows a declining trend. Young adult patients account for close to one-third of the cases and children less than 10 years account for more than a million cases annually.
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从消耗习惯到包容方式：增强私人从业者在常规疾病监测中的作用。
影响因子：
2.8
作者：
Phalkey RK;Butsch C;Belesova K;Kroll M;Kraas F
通讯作者：
Kraas F
影响因子：
11.8
作者：
Dyson, Zoe A.;Klemm, Elizabeth J.;Dougan, Gordon
通讯作者：
Dougan, Gordon
DOI：
10.1016/s0140-6736(17)32149-9
发表时间：
2017-12-02
期刊：
Lancet (London, England)
影响因子：
--
作者：
Jin C;Gibani MM;Moore M;Juel HB;Jones E;Meiring J;Harris V;Gardner J;Nebykova A;Kerridge SA;Hill J;Thomaides-Brears H;Blohmke CJ;Yu LM;Angus B;Pollard AJ
通讯作者：
Pollard AJ
影响因子：
56.3
作者：
Arinaminpathy, Nimalan;Batra, Deepak;Khaparde, Sunil;Vualnam, Thongsuanmung;Maheshwari, Nilesh;Sharma, Lokesh;Nair, Sreenivas A.;Dewan, Puneet
通讯作者：
Dewan, Puneet
影响因子：
5.4
作者：
Nandi, Arindam;Megiddo, Itamar;Laxminarayan, Ramanan
通讯作者：
Laxminarayan, Ramanan