Before and after: craving, mood, and background stress in the hours surrounding drug use and stressful events in patients with opioid-use disorder.
Before and after: craving, mood, and background stress in the hours surrounding drug use and stressful events in patients with opioid-use disorder.
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DOI：
10.1007/s00213-018-4966-9
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发表时间：
2018-09
影响因子：
3.4
通讯作者：
Epstein DH
中科院分区：
文献类型：
--
作者：
Preston KL;Kowalczyk WJ;Phillips KA;Jobes ML;Vahabzadeh M;Lin JL;Mezghanni M;Epstein DH
特定事件的生态瞬时评估通常更关注前因和伴随而不是后果。检查精神状态之前和之后的离散事件的压力和药物使用。在长达16周的时间里，接受阿片类激动剂治疗的门诊患者携带智能手机，他们在智能手机上启动了压力事件（SE）或药物使用失误（DU）的条目，并在随机提示（RP）时每天三次。参与者评估他们的压力，阿片类药物的渴望，可卡因的渴望和情绪。对事件发生后5小时内的RP条目进行分析，并与其他RP进行比较。压力，消极情绪和渴望一般较高之前和之后DU和SE相比，背景水平的参与者至少有一个DU（n = 149）或SE（n = 158）。在DU之前，消极情绪，阿片类药物渴望和可卡因渴望增加，但不是背景压力。在SE之前，背景压力，阿片类药物渴望和可卡因渴望增加，但不是消极情绪。这些变化在事件发生后比之前更易变。DU和SE与积极情绪均无显著相关。应激事件条目之前，压力增加，但在药物使用之前不太明显。在吸毒和压力事件发生前的几个小时内，渴望会增加，在这两种事件发生后的几个小时内，渴望会继续增加。这些结果表明，药物使用和渴望之间的联系比药物使用和压力之间的联系更强。药物使用的失误并没有改善情绪或减轻压力，至少在我们的一小时箱时间分辨率下没有，这表明如果存在这种好处，它们是短暂的。
Ecological momentary assessment (EMA) of specific events usually focuses more on antecedents and concomitants than on aftermaths. To examine mental state both before and after discrete episodes of stress and drug use. For up to 16 weeks, outpatients on opioid-agonist treatment carried smartphones on which they initiated entries for stressful events (SEs) or lapses to drug use (DUs), and thrice daily when randomly prompted (RPs). Participants rated their stress, opioid craving, cocaine craving, and moods. RP entries within 5 hours of an event were analyzed and compared to other RPs. Stress, negative mood, and craving were generally higher before and after DUs and SEs compared to background levels in participants with at least one DU (n=149) or SE (n=158). Before DUs, there were increases in negative mood, opioid craving, and cocaine craving, but not background stress. Before SEs, there were increases in background stress, opioid craving, and cocaine craving, but not negative mood. These changes were more variable after events than before. Neither DUs nor SEs were significantly related to positive mood. Stress increased before stressful-event entries, but was less evident before drug use. Craving increased in the hours before drug use and stressful events—and remained elevated in the hours after either event. These results suggest a stronger link between drug use and craving than between drug use and stress. Lapses to drug use did not improve mood or reduce stress, at least not at our one-hour-bin time resolution, suggesting that if such benefits exist, they are brief.
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影响因子：
25.8
作者：
Gustafson, David H.;McTavish, Fiona M.;Chih, Ming-Yuan;Atwood, Amy K.;Johnson, Roberta A.;Boyle, Michael G.;Levy, Michael S.;Driscoll, Hilary;Chisholm, StevenM.;Dillenburg, Lisa;Isham, Andrew;Shah, Dhavan
通讯作者：
Shah, Dhavan
影响因子：
7.4
作者：
Businelle MS;Ma P;Kendzor DE;Frank SG;Wetter DW;Vidrine DJ
通讯作者：
Vidrine DJ
影响因子：
1.9
作者：
MCLELLAN, AT;LUBORSKY, L;OBRIEN, CP
通讯作者：
OBRIEN, CP
影响因子：
33.9
作者：
Rudd, Rose A.;Seth, Puja;Scholl, Lawrence
通讯作者：
Scholl, Lawrence
影响因子：
12.7
作者：
Zibbell, Jon E.;Asher, Alice K.;Holtzman, Deborah
通讯作者：
Holtzman, Deborah