Multi-level regulation of cellular glycosylation: from genes to transcript to enzyme to structure.
Multi-level regulation of cellular glycosylation: from genes to transcript to enzyme to structure.
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DOI：
10.1016/j.sbi.2016.09.013
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发表时间：
2016-10
影响因子：
6.8
通讯作者：
Mahal, Lara K.
中科院分区：
文献类型：
--
作者：
Neelamegham, Sriram;Mahal, Lara K.
糖基化是一种普遍存在的哺乳动物翻译后修饰，既修饰了大多数表达的蛋白质，又调节了它们的功能。细胞聚糖的生物合成由几百种统称为“糖酶”的酶促进。这些酶的表达和活性在转录、翻译和翻译后水平受到控制。湿实验室的新进展提供了在这些多个层面收集大规模数据的分析方法，关系数据库开始整理这些结果，计算机模型开始跨尺度整合这些信息，以获得新的知识。这些活动可能有助于定性和定量绘制调节蛋白质、细胞和组织中聚糖产生和功能的途径。
Glycosylation is a ubiquitous mammalian post-translational modification that both decorates a majority of expressed proteins and regulates their function. Cellular glycan biosynthesis is facilitated by a few hundred enzymes that are collectively termed ‘glycoenzymes’. The expression and activity of these enzymes is controlled at the transcription, translation and post-translation levels. New wet-lab advances are providing analytical methods to collect large-scale data at these multiple levels, relational databases are starting to collate these results, and computer models are beginning to integrate this information across scales in order to gain new knowledge. These activities are likely to enable the qualitative and quantitative mapping of pathways regulating glycan production and function in proteins, cells and tissue.
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