Evolution of efficient pathways for degradation of anthropogenic chemicals.
Evolution of efficient pathways for degradation of anthropogenic chemicals.
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DOI：
10.1038/nchembio.197
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发表时间：
2009-08
影响因子：
14.8
通讯作者：
Copley, Shelley D.
中科院分区：
文献类型：
--
作者：
Copley, Shelley D.
Anthropogenic compounds used as pesticides, solvents, and explosives often persist in the environment and can cause toxicity to humans and wildlife. The persistence of anthropogenic compounds is due to their recent introduction into the environment; microbes in soil and water have had relatively little time to evolve efficient mechanisms for degradation of these novel compounds. Some anthropogenic compounds are easily degraded, while others are degraded very slowly or only partially, leading to accumulation of toxic products. This review examines the factors that affect the ability of microbes to degrade anthropogenic compounds and the mechanisms by which novel pathways emerge in nature. New approaches for engineering microbes with enhanced degradative abilities include assembly of pathways using enzymes from multiple organisms, directed evolution of inefficient enzymes, and genome shuffling to improve microbial fitness under the challenging conditions posed by contaminated environments.
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影响因子：
14.9
作者：
Kanehisa M;Araki M;Goto S;Hattori M;Hirakawa M;Itoh M;Katayama T;Kawashima S;Okuda S;Tokimatsu T;Yamanishi Y
通讯作者：
Yamanishi Y
DOI：
10.1073/pnas.262420099
发表时间：
2002-12-24
影响因子：
11.1
作者：
Baker, K;Bleczinski, C;Cornish, VW
通讯作者：
Cornish, VW
影响因子：
15
作者：
Lin, HN;Tao, HY;Cornish, VW
通讯作者：
Cornish, VW
影响因子：
4.4
作者：
Dai, MH;Copley, SD
通讯作者：
Copley, SD
影响因子：
4.4
作者：
He, ZQ;Spain, JC
通讯作者：
Spain, JC