Systematic coarse-graining of spectrin-level red blood cell models.

Systematic coarse-graining of spectrin-level red blood cell models.
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DOI:
10.1016/j.cma.2010.02.001
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发表时间:
2010-06-01
影响因子:
7.2
通讯作者:
Karniadakis GE
Karniadakis GE
中科院分区:
工程技术1区
文献类型:
--
作者:
Fedosov DA;Caswell B;Karniadakis GE

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我们提出了一个严格的程序来获得粗粒度的红细胞(RBC)模型,产生准确的机械响应。基于半解析理论的线性和非线性弹性性质的健康和感染的红细胞在疟疾可以匹配的光镊拉伸实验中获得的。本分析预测正确的膜杨氏模量相比,约50%的误差,由以前的模型预测。此外,我们开发了一个无应力模型,避免了一些现有的RBC模型的陷阱,如非光滑或控制不良的平衡形状和依赖的初始三角质量的机械性能。在这里,我们采用耗散粒子动力学的实施,但所提出的模型是通用的,适用于许多现有的连续介质和粒子为基础的数值方法。
We present a rigorous procedure to derive coarse-grained red blood cell (RBC) models, which yield accurate mechanical response. Based on a semi-analytic theory the linear and nonlinear elastic properties of healthy and infected RBCs in malaria can be matched with those obtained in optical tweezers stretching experiments. The present analysis predicts correctly the membrane Young’s modulus in contrast to about 50% error in predictions by previous models. In addition, we develop a stress-free model which avoids a number of pitfalls of existing RBC models, such as non-smooth or poorly controlled equilibrium shape and dependence of the mechanical properties on the initial triangulation quality. Here we employ dissipative particle dynamics for the implementation but the proposed model is general and suitable for use in many existing continuum and particle-based numerical methods.
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发表时间: 1998-05-01
影响因子: 3.4
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