Long-Chain Polyunsaturated Fatty Acids and Their Metabolites Regulate Inflammation in Age-Related Macular Degeneration.
Long-Chain Polyunsaturated Fatty Acids and Their Metabolites Regulate Inflammation in Age-Related Macular Degeneration.
复制标题
DOI：
10.2147/jir.s347231
复制
发表时间：
2022
影响因子：
4.5
通讯作者：
Gong Y
中科院分区：
文献类型：
--
作者：
Ren J;Ren A;Deng X;Huang Z;Jiang Z;Li Z;Gong Y
年龄相关性黄斑变性（AMD）是一种致盲性眼病，其发病率随着年龄的增长而急剧增加。AMD的病因复杂，包括衰老、脂质代谢异常、慢性炎症和氧化应激。长链多不饱和脂肪酸（LCPUFA）对眼睛的结构和功能至关重要。本文综述了LCPUFA对AMD炎症反应的调节作用。LCPUFA与衰老、自噬和慢性炎症有关。它们被各种酶代谢为促炎和抗炎代谢物。这些代谢物刺激炎症反应氧化应激，引起先天性和获得性免疫反应。本文还讨论了其可能的临床应用，为预防和治疗AMD和其他年龄相关疾病提供了新的靶点。
Age-related macular degeneration (AMD) is a blinding eye disease, whose incidence strongly increases with ages. The etiology of AMD is complex, including aging, abnormal lipid metabolism, chronic inflammation and oxidative stress. Long-chain polyunsaturated fatty acids (LCPUFA) are essential for ocular structures and functions. This review summarizes the regulatory effects of LCPUFA on inflammation in AMD. LCPUFA are related to aging, autophagy and chronic inflammation. They are metabolized to pro- and anti-inflammatory metabolites by various enzymes. These metabolites stimulate inflammation in response to oxidative stress, causing innate and acquired immune responses. This review also discusses the possible clinical applications, which provided novel targets for the prevention and treatment of AMD and other age-related diseases.
影响因子：
2.6
作者：
Koscielniak A;Serafin M;Duda M;Oles T;Zadlo A;Broniec A;Berdeaux O;Gregoire S;Bretillon L;Sarna T;Pawlak A
通讯作者：
Pawlak A