Tunneling Nanotube: An Enticing Cell-Cell Communication in the Nervous System.
Tunneling Nanotube: An Enticing Cell-Cell Communication in the Nervous System.
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本文综述了隧道纳米管（TNT）和TNT样结构在神经系统中的作用。TNT是薄的中空质膜突起，其将一个细胞的腔直接连接到另一个细胞的腔，从而在两个连接的细胞之间转移不同的货物。TNT已被证明在神经元发育中发挥非常突出的作用，并作为大脑中神经退行性疾病的高速公路。在这里，我们讨论了不同的关键方面的TNTs，如他们的架构，TNTs的参与在不同的病理和生理条件下的神经系统，并参与其形成的机制。在这篇综述中，我们还讨论了TNT研究所面临的不同挑战及其未来前景。神经科学领域正在迅速发展，不断发现新的见解和发现。在已经显示出巨大研究潜力的领域中，隧道纳米管（TNT）已经成为一个有前途的研究课题。这些微小的结构充当细胞之间细胞物质转移的管道，代表了具有重要意义的通信机制。特别是，由TNT促进的脑内各种细胞类型之间的相互作用，包括神经元，星形胶质细胞，少突胶质细胞，神经胶质细胞和小胶质细胞，对于这个复杂器官的正常发育和最佳功能是必不可少的。TNT参与神经退行性疾病，如阿尔茨海默病、亨廷顿病和帕金森病，已经引起了极大的关注。这些疾病的特征是神经元的进行性变性和随后的脑功能下降。研究预测，TNT可能在病理因素的传播和扩散中起关键作用，有助于这些疾病的进展。因此，人们越来越有兴趣了解神经系统内TNT的确切功能和机制。这篇综述文章，基于我们最近的工作，对恒河猴介导的TNTs，旨在探讨TNTs在脑内的功能，并调查其对神经退行性疾病的影响。利用从研究TNT中获得的知识可以为设计可以阻止神经退行性疾病进展的靶向治疗提供新的机会。
This review highlights the role of tunneling nanotubes (TNTs) and TNT-like structures in the nervous system. TNTs are thin, hollow plasma membrane projections that directly connect the lumen of one cell to the lumen of another cell, thereby transferring different cargoes between the two connected cells. TNTs have been shown to play very prominent roles in neuronal development and serve as highways for neurodegenerative diseases in the brain. Here, we discuss different crucial aspects of TNTs like their architecture, TNTs’ involvement in different pathological and physiological conditions in the nervous system, and the mechanisms involved in their formation. In this review, we also discuss different challenges involved in TNT research and its future prospects. The field of neuroscience is rapidly progressing, continuously uncovering new insights and discoveries. Among the areas that have shown immense potential in research, tunneling nanotubes (TNTs) have emerged as a promising subject of study. These minute structures act as conduits for the transfer of cellular materials between cells, representing a mechanism of communication that holds great significance. In particular, the interplay facilitated by TNTs among various cell types within the brain, including neurons, astrocytes, oligodendrocytes, glial cells, and microglia, can be essential for the normal development and optimal functioning of this complex organ. The involvement of TNTs in neurodegenerative disorders, such as Alzheimer’s disease, Huntington’s disease, and Parkinson’s disease, has attracted significant attention. These disorders are characterized by the progressive degeneration of neurons and the subsequent decline in brain function. Studies have predicted that TNTs likely play critical roles in the propagation and spread of pathological factors, contributing to the advancement of these diseases. Thus, there is a growing interest in understanding the precise functions and mechanisms of TNTs within the nervous system. This review article, based on our recent work on Rhes-mediated TNTs, aims to explore the functions of TNTs within the brain and investigate their implications for neurodegenerative diseases. Using the knowledge gained from studying TNTs could offer novel opportunities for designing targeted treatments that can stop the progression of neurodegenerative disorders.
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影响因子：
3.7
作者：
Freeman D;Cedillos R;Choyke S;Lukic Z;McGuire K;Marvin S;Burrage AM;Sudholt S;Rana A;O'Connor C;Wiethoff CM;Campbell EM
通讯作者：
Campbell EM
线粒体转移是一种新型的疾病诊断和治疗治疗方法。
影响因子：
5.6
作者：
通讯作者：
--
影响因子：
4.8
作者：
Padmanabhan, Sreedevi;Manjithaya, Ravi
通讯作者：
Manjithaya, Ravi
影响因子：
4.6
作者：
Dieriks BV;Park TI;Fourie C;Faull RL;Dragunow M;Curtis MA
通讯作者：
Curtis MA
DOI：
10.1016/j.bbadis.2021.166246
发表时间：
2021-08-19
影响因子：
6.2
作者：
Dilna, Aysha;Deepak, K., V;Nath, Sangeeta
通讯作者：
Nath, Sangeeta