Amyloid-Beta (1-40) Peptide and Subclinical Cardiovascular Disease.

Amyloid-Beta (1-40) Peptide and Subclinical Cardiovascular Disease.
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β-淀粉样蛋白 (1-40) 肽和亚临床心血管疾病。

DOI:
10.1016/j.jacc.2018.06.027
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发表时间:
2018
影响因子:
24
通讯作者:
Stellos,Konstantinos
Stellos,Konstantinos
中科院分区:
医学1区
文献类型:
--
作者:
Stamatelopoulos,Kimon;Pol,ChristineJ;Ayers,Colby;Georgiopoulos,Georgios;Gatsiou,Aikaterini;Brilakis,EmmanouilS;Khera,Amit;Drosatos,Konstantinos;deLemos,JamesA;Stellos,Konstantinos

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Amyloid-beta (1-40)(Ab40), a peptide with proinflammatory and proatherosclerotic properties, is associated with arterial aging (1) and with major adverse cardiovascular events in patients with stable coronary heart disease, heart failure, or acute coronary syndrome (1–3). However, the clinical significance of Ab40 in the general population without clinically overt cardiovascular disease (CVD) is unknown. We sought to determine the association of circulating Ab40 levels with facets of subclinical cardiac and coronary artery disease in the general population.
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