Aβ Amyloid Pathology Affects the Hearts of Patients With Alzheimer's Disease: Mind the Heart.
Aβ Amyloid Pathology Affects the Hearts of Patients With Alzheimer's Disease: Mind the Heart.
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DOI：
10.1016/j.jacc.2016.08.073
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发表时间：
2016-12-06
影响因子：
24
通讯作者：
del Monte, Federica
中科院分区：
文献类型：
--
作者：
Troncone, Luca;Luciani, Marco;Coggins, Matthew;Wilker, Elissa H.;Ho, Cheng-Ying;Codispoti, Kari Elise;Frosch, Matthew P.;Kayed, Rakez;del Monte, Federica
Individually, heart failure (HF) and Alzheimer Disease (AD) are severe threats to population health, and their potential coexistence is an alarming prospect. In addition to sharing analogous epidemiological and genetic profiles, biochemical characteristics, and common triggers, we recently recognized common molecular and pathological features between the 2 conditions. Whereas cognitive impairment has been linked to HF through perfusion defects, angiopathy, and inflammation, whether patients with AD present with myocardial dysfunction, and if the 2 conditions bear a common pathogenesis as neglected siblings is unknown. Here we investigated if amyloid beta (Aβ) protein aggregates are present in the hearts of patients with a primary diagnosis of AD, affecting myocardial function. We examined myocardial function in a retrospective cross-sectional study from a cohort of AD patients and age-matched controls. Imaging and proteomics approaches were used to identify and quantify Aβ deposits in AD heart and brain specimens compared to controls. Cell shortening and calcium transients were measured on isolated adult cardiomyocytes. Echocardiographic measurements of myocardial function suggest that patients with AD present with an anticipated diastolic dysfunction. As in the brain, Aβ40 and Aβ42 are present in the heart, and their expression is increased in AD. Here we provide the first report of the presence of compromised myocardial function and intramyocardial deposits of Aβ in AD patients. Our findings depict a novel biological framework in which AD may be viewed either as a systemic disease or as a metastatic disorder leading to heart, and possibly multiorgan failure. AD and HF are both debilitating and life-threatening conditions, affecting enormous patient populations. Our findings underline a previously dismissed problem of a magnitude that will require new diagnostic approaches and treatments for brain and heart disease, and their combination.
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影响因子：
11.1
作者：
Cermakova P;Eriksdotter M;Lund LH;Winblad B;Religa P;Religa D
通讯作者：
Religa D
DOI：
10.1016/j.bbapap.2010.04.001
发表时间：
2010-07
期刊：
Biochimica et biophysica acta
影响因子：
--
作者：
Biancalana M;Koide S
通讯作者：
Koide S
影响因子：
9.8
作者：
Li, Duanxiang;Parks, Sharie B.;Hershberger, Ray E.
通讯作者：
Hershberger, Ray E.
DOI：
10.1073/pnas.82.12.4245
发表时间：
1985-01-01
影响因子：
11.1
作者：
MASTERS, CL;SIMMS, G;BEYREUTHER, K
通讯作者：
BEYREUTHER, K
影响因子：
2.7
作者：
Cummings, BJ;Head, E;Cotman, CW
通讯作者：
Cotman, CW