Functional specializations of human epidermal Langerhans cells and CD14+ dermal dendritic cells.
Functional specializations of human epidermal Langerhans cells and CD14+ dermal dendritic cells.
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DOI：
10.1016/j.immuni.2008.07.013
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发表时间：
2008-09-19
期刊：
影响因子：
32.4
通讯作者：
Ueno, Hideki
中科院分区：
文献类型：
--
作者：
Klechevsky, Eynav;Morita, Rimpei;Liu, Maochang;Cao, Yanying;Coquery, Sebastien;Thompson-Snipes, LuAnn;Briere, Francine;Chaussabel, Damien;Zurawski, Gerard;Palucka, A. Karolina;Reiter, Yoram;Banchereau, Jacques;Ueno, Hideki
关于人皮肤髓系DC亚群、表皮CD207+朗格汉斯细胞（LCs）和真皮CD14+ DC的功能差异知之甚少。我们发现CD14+ dc将CD4+ T细胞转化为细胞，诱导naïve B细胞转换同型并成为浆细胞。LCs优先诱导分泌Th2细胞因子的CD4+ T细胞分化，并且在启动和交叉注入naïve CD8+ T细胞方面非常有效。第三种DC群体，CD14- cd207 - cd1a + DC群体，存在于真皮层，可以比CD14+ DC更好地激活CD8+ T细胞，但比lc效率低。因此，人体皮肤显示三个DC亚群，其中两个，即CD14+ DC和lc，显示功能特化；分别优先激活体液免疫或细胞免疫
Little is known on the functional differences of the human skin myeloid DC subsets, epidermal CD207+ Langerhans cells (LCs) and dermal CD14+ DCs. We show that CD14+ DCs prime CD4+ T cells into cells that induce naïve B cells to switch isotype and become plasma cells. LCs preferentially induce the differentiation of CD4+ T cells secreting Th2 cytokines and are remarkably efficient at priming and crosspriming naïve CD8+ T cells. A third DC population, CD14-CD207-CD1a+ DC population, which resides in the dermis can activate CD8+ T cells better than CD14+ DCs but less efficiently than LCs. Thus, human skin display three DC subsets, two of them i.e. CD14+ DCs and LCs, display functional specializations; the preferential activation of humoral or cellular immunity respectively.
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DOI：
10.1084/jem.20071966
发表时间：
2007-12-24
期刊：
The Journal of experimental medicine
影响因子：
--
作者：
Bursch LS;Wang L;Igyarto B;Kissenpfennig A;Malissen B;Kaplan DH;Hogquist KA
通讯作者：
Hogquist KA
影响因子：
6.5
作者：
Nestle, FO;Filgueira, L;Burg, G
通讯作者：
Burg, G
影响因子：
5.4
作者：
Cao, Tinghua;Ueno, Hideki;Banchereau, Jacques
通讯作者：
Banchereau, Jacques
影响因子：
30.5
作者：
Belz, Gabrielle T.;Bedoui, Sammy;Heath, William R.
通讯作者：
Heath, William R.
影响因子：
32.4
作者：
Kaplan, DH;Jenison, MC;Shlomchik, MJ
通讯作者：
Shlomchik, MJ