Gelation of highly entangled hydrophobic macromolecular fluid for ultrastrong underwater in situ fast tissue adhesion.
Gelation of highly entangled hydrophobic macromolecular fluid for ultrastrong underwater in situ fast tissue adhesion.
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DOI：
10.1126/sciadv.abm9744
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发表时间：
2022-05-20
期刊：
影响因子：
13.6
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中科院分区：
文献类型：
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虽然强大的水下生物粘附对于许多生物医学应用很重要，但设计在体液存在下执行的粘合剂被证明是一个挑战。为了解决这个问题，我们提出了一种水下和原位适用的疏水粘合剂（UIHA）组成的聚二甲基硅氧烷，缠结的大分子硅油，和反应性硅烷。疏水性流体取代了边界水，形成原位凝胶，结合到组织上，并实现了优异的水下粘附强度。其在猪皮上的水下搭接剪切粘附力显著高于氰基丙烯酸酯和纤维蛋白胶，表现出优异的耐水性。UIHA对猪皮的破裂压力比纤维蛋白胶高10倍。细胞相容性UIHA成功密封了大鼠、猪、兔和犬的破裂动脉、皮肤和肺。总之，高度缠结的疏水性大分子流体的凝胶化提供了一种制备水下生物粘合剂的方法，该粘合剂具有与组织的强粘合性和优异的耐水性。凝胶网络与防水大分子交织，迅速而牢固地密封受伤的动脉、肺、皮肤和颅骨。
Although strong underwater bioadhesion is important for many biomedical applications, designing adhesives to perform in the presence of body fluids proves to be a challenge. To address this, we propose an underwater and in situ applicable hydrophobic adhesive (UIHA) composed of polydimethylsiloxane, entangled macromolecular silicone fluid, and a reactive silane. The hydrophobic fluid displaced the boundary water, formed an in situ gel, bonded to tissues, and achieved exceptional underwater adhesion strength. Its underwater lap shear adhesion on porcine skin was significantly higher than that of cyanoacrylate and fibrin glues, demonstrating excellent water resistance. The burst pressure of UIHA on porcine skin was 10 times higher than that of fibrin glue. The cytocompatible UIHA successfully sealed ruptured arteries, skin, and lungs in rats, pigs, rabbits, and dogs. Together, the gelation of highly entangled hydrophobic macromolecular fluid provided a means to prepare underwater bioadhesives with strong bonding to tissues and excellent water resistance. The gel network interweaving with water-repellent macromolecules rapidly and firmly sealed wounded artery, lung, skin, and skull.
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通过精确定制受限聚合物流体的松弛来获得超高能量耗散弹性体
影响因子：
16.6
作者：
Huang J;Xu Y;Qi S;Zhou J;Shi W;Zhao T;Liu M
通讯作者：
Liu M
影响因子：
14
作者：
Jeon, Eun Young;Hwang, Byeong Hee;Cha, Hyung Joon
通讯作者：
Cha, Hyung Joon
影响因子：
29.4
作者：
Liu, Xi;Shi, Lianxin;Wang, Shutao
通讯作者：
Wang, Shutao
影响因子：
9.7
作者：
Lee BP;Messersmith PB;Israelachvili JN;Waite JH
通讯作者：
Waite JH
DOI：
10.1126/science.aah6362
发表时间：
2017-07-28
期刊：
Science (New York, N.Y.)
影响因子：
--
作者：
Li J;Celiz AD;Yang J;Yang Q;Wamala I;Whyte W;Seo BR;Vasilyev NV;Vlassak JJ;Suo Z;Mooney DJ
通讯作者：
Mooney DJ