All-systolic first-pass myocardial rest perfusion at a long saturation time using simultaneous multi-slice imaging and compressed sensing acceleration.
All-systolic first-pass myocardial rest perfusion at a long saturation time using simultaneous multi-slice imaging and compressed sensing acceleration.
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DOI：
10.1002/mrm.28712
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发表时间：
2021-08
影响因子：
3.3
通讯作者：
Roujol S
中科院分区：
文献类型：
--
作者：
Ferrazzi G;McElroy S;Neji R;Kunze KP;Nazir MS;Speier P;Stäb D;Forman C;Razavi R;Chiribiri A;Roujol S
实现具有长饱和时间的全收缩首过静息心肌灌注。通过模拟和替代测量研究灌注对比度和暗边缘伪影的变化。模拟研究心肌灌注缺陷对比度和血液心肌信号比的最佳饱和时间。采用长/短饱和时间（LTS/STS）的两个饱和恢复块对收缩末期和舒张末期的3个切片进行成像。同时多层面平衡稳态自由旋进成像和压缩感知加速相结合。在10名患者中，将该序列与3个逐层临床方案进行了比较。定量评估对比前心肌峰值和血液-心肌信号比，以及定性评估感知SNR、图像质量、模糊和暗边缘伪影。模拟结果显示，在0.075 mmol/kg的推注剂量下，240470 ms的LTS导致心肌灌注缺损对比度比STS = 120 ms相对增加34% ± 9%-28% ± 27%，同时在峰值心肌处降低18% ± 10%-32% ± 14%的血液-心肌信号比。在0.05 mmol/kg剂量下，LTS为320-570 ms，心肌灌注缺损对比度增加63% ± 13%~ 62% ± 29%。在所有患者中，LTS导致峰值心肌处的心肌峰值前对比度平均增加59%（P < .001），峰值血液/心肌处的血液-心肌信号比降低47%（P < .001）和15%（P < .001）。与临床方案相比，LTS改善了运动鲁棒性（P = .002）、图像质量（P < .001），并减少了暗边缘伪影（P = .008）。全收缩期静息灌注可通过同时多切片和压缩感知加速度相结合来实现，从而实现3切片心脏覆盖，减少运动和暗边缘伪影。数值模拟表明，心肌灌注缺陷对比度增加在LTS。
To enable all-systolic first-pass rest myocardial perfusion with long saturation times. To investigate the change in perfusion contrast and dark rim artefacts through simulations and surrogate measurements. Simulations were employed to investigate optimal saturation time for myocardium-perfusion defect contrast and blood-to-myocardium signal ratios. Two saturation recovery blocks with long/short saturation times (LTS/STS) were employed to image 3 slices at end-systole and diastole. Simultaneous multi-slice balanced steady state free precession imaging and compressed sensing acceleration were combined. The sequence was compared to a 3 slice-by-slice clinical protocol in 10 patients. Quantitative assessment of myocardium-peak pre contrast and blood-to-myocardium signal ratios, as well as qualitative assessment of perceived SNR, image quality, blurring, and dark rim artefacts, were performed. Simulations showed that with a bolus of 0.075 mmol/kg, a LTS of 240470 ms led to a relative increase in myocardium-perfusion defect contrast of 34% ± 9%-28% ± 27% than a STS = 120 ms, while reducing blood-to-myocardium signal ratio by 18% ± 10%-32% ± 14% at peak myocardium. With a bolus of 0.05 mmol/kg, LTS was 320-570 ms with an increase in myocardium-perfusion defect contrast of 63% ± 13%-62% ± 29%. Across patients, LTS led to an average increase in myocardium-peak pre contrast of 59% (P < .001) at peak myocardium and a lower blood-to-myocardium signal ratio of 47% (P < .001) and 15% (P < .001) at peak blood/myocardium. LTS had improved motion robustness (P = .002), image quality (P < .001), and decreased dark rim artefacts (P = .008) than the clinical protocol. All-systolic rest perfusion can be achieved by combining simultaneous multi-slice and compressed sensing acceleration, enabling 3-slice cardiac coverage with reduced motion and dark rim artefacts. Numerical simulations indicate that myocardium-perfusion defect contrast increases at LTS.
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DOI：
10.1186/1532-429x-16-19
发表时间：
2014-02-24
期刊：
Journal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance
影响因子：
--
作者：
Motwani M;Kidambi A;Sourbron S;Fairbairn TA;Uddin A;Kozerke S;Greenwood JP;Plein S
通讯作者：
Plein S
影响因子：
24
作者：
Fihn, Stephan D.;Gardin, Julius M.;Yancy, Clyde W.
通讯作者：
Yancy, Clyde W.
影响因子：
3.3
作者：
Bieri, O;Scheffler, K
通讯作者：
Scheffler, K
影响因子：
3.3
作者：
Basha, Tamer A.;Roujol, Sebastien;Kissinger, Kraig V.;Goddu, Beth;Berg, Sophie;Manning, Warren J.;Nezafat, Reza
通讯作者：
Nezafat, Reza
影响因子：
3.3
作者：
Di Bella, EVR;Parker, DL;Sinusas, AJ
通讯作者：
Sinusas, AJ